Next Article in Journal
Soluble CD14 as a Diagnostic Biomarker for Smear-Negative HIV-Associated Tuberculosis
Previous Article in Journal
Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery
Previous Article in Special Issue
IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns
Article Menu

Export Article

Open AccessFeature PaperOpinion
Pathogens 2018, 7(1), 25;

Congenital Toxoplasmosis: A Plea for a Neglected Disease

Hospices Civils de Lyon, Institut de Parasitologie et Mycologie Médicale, Hôpital de la Croix Rousse, F-69317 Lyon, France
Waking team, Lyon Neuroscience Research Center, INSERM U1028-CNRS UMR 5292, F-69008 Lyon, France
Author to whom correspondence should be addressed.
Received: 22 January 2018 / Revised: 15 February 2018 / Accepted: 17 February 2018 / Published: 23 February 2018
(This article belongs to the Special Issue Toxoplasma gondii Infection)
Full-Text   |   PDF [204 KB, uploaded 23 February 2018]


Maternal infection by Toxoplasma gondii during pregnancy may have serious consequences for the fetus, ranging from miscarriage, central nervous system involvement, retinochoroiditis, or subclinical infection at birth with a risk of late onset of ocular diseases. As infection in pregnant women is usually symptomless, the diagnosis relies only on serological tests. Some countries like France and Austria have organized a regular serological testing of pregnant women, some others have no prenatal program of surveillance. Reasons for these discrepant attitudes are many and debatable. Among them are the efficacy of antenatal treatment and cost-effectiveness of such a program. A significant body of data demonstrated that rapid onset of treatment after maternal infection reduces the risk and severity of fetal infection. Recent cost-effectiveness studies support regular screening. This lack of consensus put both pregnant women and care providers in a difficult situation. Another reason why congenital toxoplasmosis is disregarded in some countries is the lack of precise information about its impact on the population. Precise estimations on the burden of the disease can be achieved by systematic screening that will avoid bias or underreporting of cases and provide a clear view of its outcome. View Full-Text
Keywords: congenital toxoplasmosis; mass screening; antenatal treatment efficacy; cost effectiveness congenital toxoplasmosis; mass screening; antenatal treatment efficacy; cost effectiveness
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Wallon, M.; Peyron, F. Congenital Toxoplasmosis: A Plea for a Neglected Disease. Pathogens 2018, 7, 25.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top