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IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns
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Pathogens 2018, 7(1), 25; https://doi.org/10.3390/pathogens7010025

Congenital Toxoplasmosis: A Plea for a Neglected Disease

1
Hospices Civils de Lyon, Institut de Parasitologie et Mycologie Médicale, Hôpital de la Croix Rousse, F-69317 Lyon, France
2
Waking team, Lyon Neuroscience Research Center, INSERM U1028-CNRS UMR 5292, F-69008 Lyon, France
*
Author to whom correspondence should be addressed.
Received: 22 January 2018 / Revised: 15 February 2018 / Accepted: 17 February 2018 / Published: 23 February 2018
(This article belongs to the Special Issue Toxoplasma gondii Infection)
Full-Text   |   PDF [204 KB, uploaded 23 February 2018]

Abstract

Maternal infection by Toxoplasma gondii during pregnancy may have serious consequences for the fetus, ranging from miscarriage, central nervous system involvement, retinochoroiditis, or subclinical infection at birth with a risk of late onset of ocular diseases. As infection in pregnant women is usually symptomless, the diagnosis relies only on serological tests. Some countries like France and Austria have organized a regular serological testing of pregnant women, some others have no prenatal program of surveillance. Reasons for these discrepant attitudes are many and debatable. Among them are the efficacy of antenatal treatment and cost-effectiveness of such a program. A significant body of data demonstrated that rapid onset of treatment after maternal infection reduces the risk and severity of fetal infection. Recent cost-effectiveness studies support regular screening. This lack of consensus put both pregnant women and care providers in a difficult situation. Another reason why congenital toxoplasmosis is disregarded in some countries is the lack of precise information about its impact on the population. Precise estimations on the burden of the disease can be achieved by systematic screening that will avoid bias or underreporting of cases and provide a clear view of its outcome. View Full-Text
Keywords: congenital toxoplasmosis; mass screening; antenatal treatment efficacy; cost effectiveness congenital toxoplasmosis; mass screening; antenatal treatment efficacy; cost effectiveness
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Wallon, M.; Peyron, F. Congenital Toxoplasmosis: A Plea for a Neglected Disease. Pathogens 2018, 7, 25.

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