Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria
Abstract
1. Introduction
2. Case Presentation
3. Investigations
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- WHO. World Malaria Report 2023; World Health Organization: Geneva, Switzerland, 30 November 2023; Available online: https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2023 (accessed on 31 March 2024).
- Kidney Disease: Improving Global Outcomes (KDIGO). Acute Kidney Injury Work Group KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int. Suppl. 2012, 2, 1–138. [Google Scholar]
- Lameire, N.H.; Levin, A.; Kellum, J.A.; Cheung, M.; Jadoul, M.; Winkelmayer, W.C.; Stevens, P.E.; Conference Participants. Harmonizing acute and chronic kidney disease definition and classification: Report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference. Kidney Int. 2021, 100, 516–526. [Google Scholar] [CrossRef] [PubMed]
- Marks, M.; Armstrong, M.; Walker, D.; Doherty, T. Imported falciparum malaria among adults requiring intensive care: Analysis of the literature. Malar. J. 2014, 13, 79. [Google Scholar] [CrossRef]
- Batte, A.; Berrens, Z.; Murphy, K.; Mufumba, I.; Sarangam, M.L.; Hawkes, M.T.; Conroy, A.L. Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges. Int. J. Nephrol. Renovasc. Dis. 2021, 14, 235–253. [Google Scholar] [CrossRef]
- Silva Junior, G.B.D.; Pinto, J.R.; Barros, E.J.G.; Farias, G.M.N.; Daher, E.F. Kidney involvement in malaria: An update. Rev. Inst. Med. Trop. Sao Paulo 2017, 59, e53. [Google Scholar] [CrossRef] [PubMed]
- Katsoulis, O.; Georgiadou, A.; Cunnington, A.J. Immunopathology of Acute Kidney Injury in Severe Malaria. Front. Immunol. 2021, 12, 651739. [Google Scholar] [CrossRef]
- Hawkes, M.T.; Leligdowicz, A.; Batte, A.; Situma, G.; Zhong, K.; Namasopo, S.; Opoka, R.O.; Kain, K.C.; Conroy, A.L. Pathophysiology of Acute Kidney Injury in Malaria and Non-Malarial Febrile Illness: A Prospective Cohort Study. Pathogens 2022, 11, 436. [Google Scholar] [CrossRef] [PubMed]
- WHO. Guidelines for the Treatment of Malaria, 2nd ed.; World Health Organization: Geneva, Switzerland, 2010. Available online: https://www.ncbi.nlm.nih.gov/books/NBK254223/ (accessed on 31 March 2024).
- WHO. Guidelines for the Treatment of Malaria, 3rd ed.; World Health Organization: Geneva, Switzerland, 2015; Available online: http://apps.who.int/iris/bitstream/10665/162441/1/978 9241549127_eng.pdf (accessed on 31 March 2024).
- Roussel, C.; Caumes, E.; Thellier, M.; Ndour, P.A.; Buffet, P.A.; Jauréguiberry, S. Artesunate to treat severe malaria in travellers: Review of efficacy and safety and practical implications. J. Travel Med. 2017, 24, taw093. [Google Scholar] [CrossRef]
- Rolling, T.; Agbenyega, T.; Krishna, S.; Kremsner, P.G.; Cramer, J.P. Delayed haemolysis after artesunate treatment of severe malaria—Review of the literature and perspective. Travel Med. Infect. Dis. 2015, 13, 143–149. [Google Scholar] [CrossRef]
- Leong, K.W.; Singh, K.P.; Leder, K.; Tong, S.Y.C. Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria. BMJ Case Rep. 2021, 14, e237501. [Google Scholar] [CrossRef]
- Plewes, K.; Haider, M.S.; Kingston, H.W.; Yeo, T.W.; Ghose, A.; Hossain, M.A.; Dondorp, A.M.; Turner, G.D.; Anstey, N.M. Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury. Malar J. 2015, 14, 246. [Google Scholar] [CrossRef] [PubMed]
- Jauréguiberry, S.; Ndour, P.A.; Roussel, C.; Ader, F.; Safeukui, I.; Nguyen, M.; Biligui, S.; Ciceron, L.; Mouri, O.; Kendjo, E.; et al. Postartesunate delayed haemolysis is a predictable event related to the lifesaving effect of artemisinins. Blood 2014, 124, 167–175. [Google Scholar] [CrossRef] [PubMed]
- Camprubí, D.; Pereira, A.; Rodriguez-Valero, N.; Almuedo, A.; Varo, R.; Casals-Pascual, C.; Bassat, Q.; Malvy, D.; Muñoz, J. Positive direct antiglobulin test in post-artesunate delayed haemolysis: More than a coincidence? Malar. J. 2019, 18, 123. [Google Scholar] [CrossRef] [PubMed]
- Jauréguiberry, S.; Thellier, M.; Ndour, P.A.; Ader, F.; Roussel, C.; Sonneville, R.; Mayaux, J.; Matheron, S.; Angoulvant, A.; Wyplosz, B.; et al. Delayed-onset hemolytic anaemia in patients with travel-associated severe malaria treated with artesunate, France, 2011–2013. Emerg. Infect. Dis. 2015, 21, 804–812. [Google Scholar] [CrossRef]
- Ascoli Bartoli, T.; Lepore, L.; D’Abramo, A.; Adamo, G.; Corpolongo, A.; Scorzolini, L.; Giancola, M.L.; Bevilacqua, N.; Palazzolo, C.; Mariano, A.; et al. Systematic analysis of direct antiglobulin test results in post-artesunate delayed haemolysis. Malar. J. 2021, 20, 206. [Google Scholar] [CrossRef]
- Plewes, K.; Maude, R.J.; Ghose, A.; Dondorp, A.M. Severe falciparum malaria complicated by prolonged haemolysis and rhinomaxillary mucormycosis after parasite clearance: A case report. BMC Infect. Dis. 2015, 15, 555. [Google Scholar] [CrossRef]
- Savargaonkar, D.; Das, M.K.; Verma, A.; Mitra, J.K.; Yadav, C.P.; Srivastava, B.; Anvikar, A.R.; Valecha, N. Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India. Malar. J. 2020, 19, 39. [Google Scholar] [CrossRef]
- De Nardo, P.; Oliva, A.; Giancola, M.L.; Ghirga, P.; Mencarini, P.; Bibas, M.; Nicastri, E.; Antinori, A.; Corpolongo, A. Haemolytic anaemia after oral artemether-lumefantrine treatment in a patient affected by severe imported falciparum malaria. Infection 2013, 41, 863–865. [Google Scholar] [CrossRef] [PubMed]
- Tsuchido, Y.; Nakamura-Uchiyama, F.; Toyoda, K.; Iwagami, M.; Tochitani, K.; Shinohara, K.; Hishiya, N.; Ogawa, T.; Uno, K.; Kasahara, K.; et al. Development of Delayed Hemolytic Anaemia After Treatment with Oral Artemether-Lumefantrine in Two Patients with Severe Falciparum Malaria. Am. J. Trop. Med. Hyg. 2017, 96, 1185–1189. [Google Scholar] [CrossRef]
- Lebrun, D.; Floch, T.; Brunet, A.; Julien, G.; Romaru, J.; N’Guyen, Y.; Cousson, J.; Giltat, A.; Toubas, D.; Bani-Sadr, F. Severe post-artesunate delayed onset anaemia responding to corticotherapy: A case report. J. Travel Med. 2018, 25, tax091. [Google Scholar] [CrossRef]
- Raffray, L.; Receveur, M.C.; Beguet, M.; Lauroua, P.; Pistone, T.; Malvy, D. Severe delayed autoimmune haemolytic anaemia following artesunate administration in severe malaria: A case report. Malar. J. 2014, 13, 398. [Google Scholar] [CrossRef] [PubMed]
- Boutaud, O.; Moore, K.P.; Reeder, B.J.; Harry, D.; Howie, A.J.; Wang, S.; Carney, C.K.; Masterson, T.S.; Amin, T.; Wright, D.W.; et al. Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proc. Natl. Acad. Sci. USA 2010, 107, 2699–2704. [Google Scholar] [CrossRef] [PubMed]
- Janz, D.R.; Bastarache, J.A.; Peterson, J.F.; Sills, G.; Wickersham, N.; May, A.K.; Roberts, L.J.; Ware, L.B. Association between cell-free haemoglobin, acetaminophen, and mortality in patients with sepsis: An observational study. Crit. Care Med. 2013, 41, 784–790. [Google Scholar] [CrossRef] [PubMed]
- See, E.J.; Jayasinghe, K.; Glassford, N.; Bailey, M.; Johnson, D.W.; Polkinghorne, K.R.; Toussaint, N.D.; Bellomo, R. Long-term risk of adverse outcomes after acute kidney injury: A systematic review and meta-analysis of cohort studies using consensus definitions of exposure. Kidney Int. 2019, 95, 160–172. [Google Scholar] [CrossRef] [PubMed]
Parameter | Day 0 | Day 3 | Day 12 | Day 18 | Day 21 | Day 37 | Normal Range |
---|---|---|---|---|---|---|---|
Haemoglobin (g/L) | 15.9 | 13.6 | 10.1 | 8.7 | 6.3 | 9.6 | 13.0–18.0 |
Hematocrit (%) | 46.4 | 38.6 | 28 | 25.8 | 18.5 | 27.8 | 40–52 |
Platelets (×103/μL) | 29 | 53 | 335 | 196 | 228 | 217 | 150–400 |
Cell-free haemoglobin (mg/L) | - | - | 449 | - | 696 | - | <20 in plasma <50 in serum |
Plasma haptoglobin (g/L) | - | - | - | <0.1 | - | 0.3–2 | |
Creatinine (mg/dL) | 1.45 | 5.46 | 1.7 | 1.67 | 2.38 | 1.13 | 0.7–1.3 |
Urine (mg/dL) | 67 | 161 | 48 | 43 | - | - | 18–55 |
Lactate dehydrogenase (U/L) | 647 | 689 | - | 1420 | 1958 | 425 | 125–220 |
Total bilirubin (mg/dL) | 4.74 | 8.13 | 2.14 | 2.81 | 2.81 | 0.9 | 0.3–1.2 |
Potassium (μmol/L) | 3.7 | 3.4 | 5.2 | 4.4 | 4.4 | 3.9 | 3.5–5.1 |
CRP (mg/L) | 175.7 | 239.3 | 15 | 42.1 | 25.8 | <1.0 | <5.0 |
Procalcitonin (ng/mL) | 10.94 | 26.96 | - | - | - | <0.5 | |
Venous pH | 7.412 | 7.428 | - | - | 7.386 | - | 7.35–7.45 |
Venous bicarbonate (mmol/L) | 15 | 20.8 | - | - | 19.9 | - | 22–28 |
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Kubanek, A.; Sulima, M.; Szydłowska, A.; Sikorska, K.; Renke, M. Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria. Pathogens 2024, 13, 851. https://doi.org/10.3390/pathogens13100851
Kubanek A, Sulima M, Szydłowska A, Sikorska K, Renke M. Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria. Pathogens. 2024; 13(10):851. https://doi.org/10.3390/pathogens13100851
Chicago/Turabian StyleKubanek, Alicja, Małgorzata Sulima, Aleksandra Szydłowska, Katarzyna Sikorska, and Marcin Renke. 2024. "Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria" Pathogens 13, no. 10: 851. https://doi.org/10.3390/pathogens13100851
APA StyleKubanek, A., Sulima, M., Szydłowska, A., Sikorska, K., & Renke, M. (2024). Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria. Pathogens, 13(10), 851. https://doi.org/10.3390/pathogens13100851