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Article

The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947

Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia
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Author to whom correspondence should be addressed.
Academic Editors: Bindu Nanduri and Ed Swiatlo
Pathogens 2022, 11(2), 216; https://doi.org/10.3390/pathogens11020216
Received: 18 December 2021 / Revised: 31 January 2022 / Accepted: 1 February 2022 / Published: 7 February 2022
(This article belongs to the Special Issue Streptococcus pneumoniae)
The LuxS protein, encoded by luxS, is required for the production of autoinducer 2 (AI-2) in Streptococcus pneumoniae. The AI-2 molecule serves as a quorum sensing signal, and thus regulates cellular processes such as carbohydrate utilisation and biofilm formation, as well as impacting virulence. The role of luxS in S. pneumoniae biology and lifestyle has been predominantly assessed in the laboratory strain D39. However, as biofilm formation, which is regulated by luxS, is critical for the ability of S. pneumoniae to cause otitis media, we investigated the role of luxS in a middle ear isolate, strain 947. Our results identified luxS to have a role in prevention of S. pneumoniae transition from colonisation of the nasopharynx to the ear, and in facilitating adherence to host epithelial cells. View Full-Text
Keywords: Streptococcus pneumoniae; quorum sensing; biofilms; otitis media Streptococcus pneumoniae; quorum sensing; biofilms; otitis media
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MDPI and ACS Style

Tikhomirova, A.; Brazel, E.B.; McLean, K.T.; Agnew, H.N.; Paton, J.C.; Trappetti, C. The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947. Pathogens 2022, 11, 216. https://doi.org/10.3390/pathogens11020216

AMA Style

Tikhomirova A, Brazel EB, McLean KT, Agnew HN, Paton JC, Trappetti C. The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947. Pathogens. 2022; 11(2):216. https://doi.org/10.3390/pathogens11020216

Chicago/Turabian Style

Tikhomirova, Alexandra, Erin B. Brazel, Kimberley T. McLean, Hannah N. Agnew, James C. Paton, and Claudia Trappetti. 2022. "The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947" Pathogens 11, no. 2: 216. https://doi.org/10.3390/pathogens11020216

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