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Epigenomes, Volume 8, Issue 2

June 2024 - 12 articles

Cover Story: Neuroepithelial cells (NECs) undergo symmetric cell division to produce an initial pool of cortical progenitors that later transform into radial glia cells (RGCs), which act as primary neural stem cells (NSCs). RGCs first produce Cajal-Retzius cells (CRCs), which form the preplate. RGCs next produce deep layer (DL) neurons, and subsequently upper layer (UL) neurons mostly through intermediate progenitor cells (IPCs). In later stages, RGCs acquire the ability to differentiate into glial cells and give rise to astrocytes and oligodendrocytes. During cortical development, the proliferation and differentiation of NSCs are regulated by combinations of spatiotemporally modulated cell-intrinsic epigenetic alterations and extrinsic factors, the disruption of which leads to various brain diseases. View this paper

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Review

37 Citations

7,334 Views

20 Pages

Pathogenesis of PM_2.5-Related Disorders in Different Age Groups: Children, Adults, and the Elderly

Teerachai Amnuaylojaroen and
Nichapa Parasin

Epigenomes2024, 8(2), 13;https://doi.org/10.3390/epigenomes8020013

31 March 2024

The effects of PM2.5 on human health fluctuate greatly among various age groups, influenced by a range of physiological and immunological reactions. This paper compares the pathogenesis of the disease caused by PM2.5 in people of different ages, focu...

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Article

2,418 Views

12 Pages

Epigenetic Features in Newborns Associated with Preadolescence Lung Function and Asthma Acquisition during Adolescence

Mohammad Nahian Ferdous Abrar,
Yu Jiang,
Hongmei Zhang,
Liang Li and
Hasan Arshad

Epigenomes2024, 8(2), 12;https://doi.org/10.3390/epigenomes8020012

22 March 2024

The association between newborn DNA methylation (DNAm) and asthma acquisition (AA) during adolescence has been suggested. Lung function (LF) has been shown to be associated with asthma risk and its severity. However, the role of LF in the association...

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