Impaired Interhemispheric Synchrony in Parkinson’s Disease with Fatigue
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants and Clinical Assessment
2.2. Image Acquisition
2.3. Data Preprocessing
2.4. Voxel-Mirrored Homotopic Connectivity
2.5. Statistical Analysis
3. Results
3.1. Demographic and Clinical Characteristics
3.2. Voxel-Mirrored Homotopic Connectivity
3.3. Correlation Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | PDF (n = 16) | PDNF (n = 16) | HCs (n = 15) | p Value |
---|---|---|---|---|
Age (y) a | 57.25 ± 13.98 | 63.37 ± 9.19 | 63.80 ± 5.72 | 0.147 |
Sex (F/M) b | 8/8 | 4/12 | 5/10 | 0.326 |
Education (y) c | 11.68 ± 3.43 | 11.06 ± 4.15 | 11.33 ± 3.45 | 0.922 |
MMSE c | 28.25 ± 1.34 | 28.43 ± 1.20 | 28.93 ± 1.16 | 0.317 |
Disease duration (y) d | 5.37 ± 3.52 | 6.50 ± 3.38 | NA | 0.296 |
H&Y d | 2.34 ± 0.67 | 2.00 ± 0.60 | NA | 0.130 |
UPDRS-III d | 29.00 ± 11.00 | 28.31 ± 11.72 | NA | 0.865 |
LEDD (mg/day) d | 613.67 ± 248.89 | 659.68 ± 349.92 | NA | 0.671 |
ESS d | 5.06 ± 3.67 | 4.06 ± 3.21 | NA | 0.419 |
AS d | 10.06 ± 2.69 | 8.31 ± 3.51 | NA | 0.125 |
HAMD e | 10.38 ± 4.98 | 7.94 ± 4.16 | NA | 0.143 |
HAMA e | 10.56 ± 4.75 | 8.44 ± 5.42 | NA | 0.247 |
FSS/9 a | 5.13 ± 1.06 | 2.07 ± 1.06 | 1.50 ± 0.42 | <0.001 * |
Post hoc | PDF vs. PDNF | <0.001 * | ||
PDF vs. HC | <0.001 * | |||
PDNF vs. HC | 0.089 |
Brain Regions (AAL) | Number of Voxels | MNI Coordinates | T Value | ||
---|---|---|---|---|---|
X | Y | Z | |||
PDF > PDNF | |||||
SMG | 15 | ±54 | −39 | 33 | −3.9081 |
PDF > HCs | |||||
IFG operc | 36 | ±54 | 12 | 6 | −4.7763 |
SMG | 15 | ±51 | −42 | 36 | −4.4129 |
PDNF > HCs | |||||
IFG operc | 12 | ±54 | 15 | 12 | −3.6089 |
MFG | 27 | ±42 | 33 | 36 | −3.8621 |
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Yuan, Y.-S.; Ji, M.; Gan, C.-T.; Sun, H.-M.; Wang, L.-N.; Zhang, K.-Z. Impaired Interhemispheric Synchrony in Parkinson’s Disease with Fatigue. J. Pers. Med. 2022, 12, 884. https://doi.org/10.3390/jpm12060884
Yuan Y-S, Ji M, Gan C-T, Sun H-M, Wang L-N, Zhang K-Z. Impaired Interhemispheric Synchrony in Parkinson’s Disease with Fatigue. Journal of Personalized Medicine. 2022; 12(6):884. https://doi.org/10.3390/jpm12060884
Chicago/Turabian StyleYuan, Yong-Sheng, Min Ji, Cai-Ting Gan, Hui-Min Sun, Li-Na Wang, and Ke-Zhong Zhang. 2022. "Impaired Interhemispheric Synchrony in Parkinson’s Disease with Fatigue" Journal of Personalized Medicine 12, no. 6: 884. https://doi.org/10.3390/jpm12060884