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Implementation of MALDI Mass Spectrometry Imaging in Cancer Proteomics Research: Applications and Challenges

1
Centre for Proteomics, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerpen, Belgium
2
Health Unit, VITO, Boeretang 200, 2400 Mol, Belgium
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Food & Bio-Based Products, AgResearch Ltd., Lincoln 7674, New Zealand
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Department of Pathology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
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Center for Oncological Research, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2020, 10(2), 54; https://doi.org/10.3390/jpm10020054
Received: 7 May 2020 / Revised: 12 June 2020 / Accepted: 19 June 2020 / Published: 22 June 2020
(This article belongs to the Special Issue Proteomics and Personalized Medicine)
Studying the proteome–the entire set of proteins in cells, tissues, organs and body fluids—is of great relevance in cancer research, as differential forms of proteins are expressed in response to specific intrinsic and extrinsic signals. Discovering protein signatures/pathways responsible for cancer transformation may lead to a better understanding of tumor biology and to a more effective diagnosis, prognosis, recurrence and response to therapy. Moreover, proteins can act as a biomarker or potential drug targets. Hence, it is of major importance to implement proteomic, particularly mass spectrometric, approaches in cancer research, to provide new crucial insights into tumor biology. Recently, mass spectrometry imaging (MSI) approaches were implemented in cancer research, to provide individual molecular characteristics of each individual tumor while retaining molecular spatial distribution, essential in the context of personalized disease management and medicine. View Full-Text
Keywords: MALDI mass spectrometry imaging; proteomics; proteomic profiling; cancer research; personalized medicine MALDI mass spectrometry imaging; proteomics; proteomic profiling; cancer research; personalized medicine
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Berghmans, E.; Boonen, K.; Maes, E.; Mertens, I.; Pauwels, P.; Baggerman, G. Implementation of MALDI Mass Spectrometry Imaging in Cancer Proteomics Research: Applications and Challenges. J. Pers. Med. 2020, 10, 54.

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