Mesonephric-Like Carcinosarcoma of the Ovary Associated with Low-Grade Serous Carcinoma: A Case Report
Abstract
1. Introduction
2. Case Presentation
2.1. Clinical History
2.2. Pathological Findings
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
- McFarland, M.; Quick, C.M.; McCluggage, W.G. Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: Report of a series of mesonephric-like adenocarcinomas. Histopathology 2016, 68, 1013–1020. [Google Scholar] [CrossRef] [PubMed]
- Mueller, I.; Kametriser, G.; Jacobs, V.R.; Bogner, G.; Staudach, A.; Koch, H.; Wolfrum-Ristau, P.; Schausberger, C.; Fischer, T.; Sedlmayer, F. Mesonephric adenocarcinoma of the vagina: Diagnosis and multimodal treatment of a rare tumor and analysis of worldwide experience. Strahlenther. Onkol. 2016, 192, 668–671. [Google Scholar] [CrossRef] [PubMed]
- Horn, L.C.; Hohn, A.K.; Krucken, I.; Stiller, M.; Obeck, U.; Brambs, C.E. Mesonephric-like adenocarcinomas of the uterine corpus: Report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma. J. Cancer Res. Clin. Oncol. 2020, 146, 971–983. [Google Scholar] [CrossRef] [PubMed]
- Huffman, J.W. Mesonephric remnants in the cervix. Am. J. Obstet. Gynecol. 1948, 56, 23–40. [Google Scholar] [CrossRef]
- Ferry, J.A.; Scully, R.E. Mesonephric remnants, hyperplasia, and neoplasia in the uterine cervix. A study of 49 cases. Am. J. Surg. Pathol. 1990, 14, 1100–1111. [Google Scholar] [CrossRef] [PubMed]
- WHO Classification of Tumours EB. Female Genital Tumours, 5th ed; WHO Classification of Tumours Series; International Agency for Research on Cancer: Lyon, France, 2020; Volume 4, Available online: https://tumourclassification.iarc.who.int/chapters/34 (accessed on 3 May 2021).
- Seay, K.; Akanbi, T.; Bustamante, B.; Chaudhary, S.; Goldberg, G.L. Mesonephric-like adenocarcinoma of the ovary with co-existent endometriosis: A case report and review of the literature. Gynecol. Oncol. Rep. 2020, 34, 100657. [Google Scholar] [CrossRef] [PubMed]
- McCluggage, W.G.; Vosmikova, H.; Laco, J. Ovarian Combined Low-grade Serous and Mesonephric-like Adenocarcinoma: Further Evidence for A Mullerian Origin of Mesonephric-like Adenocarcinoma. Int. J. Gynecol. Pathol. 2020, 39, 84–92. [Google Scholar] [CrossRef] [PubMed]
- Dundr, P.; Gregova, M.; Nemejcova, K.; Bartu, M.; Hajkova, N.; Hojny, J.; Struzinska, I.; Fischerova, D. Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: A case report with complex morphological and molecular analysis. Diagn. Pathol. 2020, 15, 91. [Google Scholar] [CrossRef] [PubMed]
- Mirkovic, J.; McFarland, M.; Garcia, E.; Sholl, L.M.; Lindeman, N.; MacConaill, L.; Dong, F.; Hirsch, M.; Nucci, M.R.; Quick, C.M.; et al. Targeted Genomic Profiling Reveals Recurrent KRAS Mutations in Mesonephric-like Adenocarcinomas of the Female Genital Tract. Am. J. Surg. Pathol. 2018, 42, 227–233. [Google Scholar] [CrossRef] [PubMed]
- Chapel, D.B.; Joseph, N.M.; Krausz, T.; Lastra, R.R. An Ovarian Adenocarcinoma With Combined Low-grade Serous and Mesonephric Morphologies Suggests a Mullerian Origin for Some Mesonephric Carcinomas. Int. J. Gynecol. Pathol. 2018, 37, 448–459. [Google Scholar] [CrossRef] [PubMed]
- Yamamoto, Y.; Akagi, A.; Izumi, K.; Kishi, Y. Carcinosarcoma of the uterine body of mesonephric origin. Pathol. Int. 1995, 45, 303–309. [Google Scholar] [CrossRef] [PubMed]
- Meguro, S.; Yasuda, M.; Shimizu, M.; Kurosaki, A.; Fujiwara, K. Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: A case report and review of the literature. Diagn. Pathol. 2013, 8, 74. [Google Scholar] [CrossRef] [PubMed]
- Roma, A.A. Mesonephric carcinosarcoma involving uterine cervix and vagina: Report of 2 cases with immunohistochemical positivity For PAX2, PAX8, and GATA-3. Int. J. Gynecol. Pathol. 2014, 33, 624–629. [Google Scholar] [CrossRef] [PubMed]
- Ribeiro, B.; Silva, R.; Dias, R.; Patricio, V. Carcinosarcoma of the uterine cervix: A rare pathological finding originating from mesonephric remnants. BMJ Case Rep. 2019, 12. [Google Scholar] [CrossRef] [PubMed]
- Howitt, B.E.; Nucci, M.R. Mesonephric proliferations of the female genital tract. Pathology 2018, 50, 141–150. [Google Scholar] [CrossRef] [PubMed]
- Howitt, B.E.; Emori, M.M.; Drapkin, R.; Gaspar, C.; Barletta, J.A.; Nucci, M.R.; McCluggage, W.G.; Oliva, E.; Hirsch, M.S. GATA3 Is a Sensitive and Specific Marker of Benign and Malignant Mesonephric Lesions in the Lower Female Genital Tract. Am. J. Surg. Pathol. 2015, 39, 1411–1419. [Google Scholar] [CrossRef] [PubMed]
- Kenny, S.L.; McBride, H.A.; Jamison, J.; McCluggage, W.G. Mesonephric adenocarcinomas of the uterine cervix and corpus: HPV-negative neoplasms that are commonly PAX8, CA125, and HMGA2 positive and that may be immunoreactive with TTF1 and hepatocyte nuclear factor 1-beta. Am. J. Surg. Pathol. 2012, 36, 799–807. [Google Scholar] [CrossRef] [PubMed]
Low-Grade Serous Component | Mesonephric-Like Component | Sarcomatous Component | |
---|---|---|---|
CK7 | + | + | + |
PAX8 | + | + | + |
ER | + | - | - |
PR | + | - | - |
Calretinin | - | + | + |
CD10 | - | + | + |
TTF-1 | - | + | + |
GATA-3 | - | + | + |
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d’Amati, A.; Pezzuto, F.; Serio, G.; Marzullo, A.; Fortarezza, F.; Lettini, T.; Cazzato, G.; Cormio, G.; Resta, L. Mesonephric-Like Carcinosarcoma of the Ovary Associated with Low-Grade Serous Carcinoma: A Case Report. Diagnostics 2021, 11, 827. https://doi.org/10.3390/diagnostics11050827
d’Amati A, Pezzuto F, Serio G, Marzullo A, Fortarezza F, Lettini T, Cazzato G, Cormio G, Resta L. Mesonephric-Like Carcinosarcoma of the Ovary Associated with Low-Grade Serous Carcinoma: A Case Report. Diagnostics. 2021; 11(5):827. https://doi.org/10.3390/diagnostics11050827
Chicago/Turabian Styled’Amati, Antonio, Federica Pezzuto, Gabriella Serio, Andrea Marzullo, Francesco Fortarezza, Teresa Lettini, Gerardo Cazzato, Gennaro Cormio, and Leonardo Resta. 2021. "Mesonephric-Like Carcinosarcoma of the Ovary Associated with Low-Grade Serous Carcinoma: A Case Report" Diagnostics 11, no. 5: 827. https://doi.org/10.3390/diagnostics11050827
APA Styled’Amati, A., Pezzuto, F., Serio, G., Marzullo, A., Fortarezza, F., Lettini, T., Cazzato, G., Cormio, G., & Resta, L. (2021). Mesonephric-Like Carcinosarcoma of the Ovary Associated with Low-Grade Serous Carcinoma: A Case Report. Diagnostics, 11(5), 827. https://doi.org/10.3390/diagnostics11050827