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Diagnostics
Volume 11
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10.3390/diagnostics11010085
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Article

Associations between Statin/Omega3 Usage and MRI-Based Radiomics Signatures in Prostate Cancer

by
Yu Shi
1,
Ethan Wahle
2,
Qian Du
1,
Luke Krajewski
2,
Xiaoying Liang
3,
Sumin Zhou
2,
Chi Zhang
1,*,
Michael Baine
2,* and
Dandan Zheng
2,*
1
Department of Biological Science, University of Nebraska Lincoln, Lincoln, NE 68588, USA
2
Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68189, USA
3
Department of Radiation Oncology, University of Florida Proton Institute, Jacksonville, FL 32206, USA
*
Authors to whom correspondence should be addressed.
Diagnostics 2021, 11(1), 85; https://doi.org/10.3390/diagnostics11010085
Submission received: 3 November 2020 / Revised: 31 December 2020 / Accepted: 5 January 2021 / Published: 7 January 2021
(This article belongs to the Special Issue Role of Imaging and Artificial Intelligence in Prostate Cancer)
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Abstract

Prostate cancer is the most common noncutaneous cancer and the second leading cause of cancer deaths among American men. Statins and omega-3 are two medications recently found to correlate with prostate cancer risk and aggressiveness, but the observed associations are complex and controversial. We therefore explore the novel application of radiomics in studying statin and omega-3 usage in prostate cancer patients. On MRIs of 91 prostate cancer patients, two regions of interest (ROIs), the whole prostate and the peripheral region of the prostate, were manually segmented. From each ROI, 944 radiomic features were extracted after field bias correction and normalization. Heatmaps were generated to study the radiomic feature patterns against statin or omega-3 usage. Radiomics models were trained on selected features and evaluated with 500-round threefold cross-validation for each drug/ROI combination. On the 1500 validation datasets, the radiomics model achieved average AUCs of 0.70, 0.74, 0.78, and 0.72 for omega-3/prostate, omega-3/peripheral, statin/prostate, and statin/peripheral, respectively. As the first study to analyze radiomics in relation to statin and omega-3 uses in prostate cancer patients, our study preliminarily established the existence of imaging-identifiable tissue-level changes in the prostate and illustrated the potential usefulness of radiomics for further exploring these medications’ effects and mechanisms in prostate cancer.
Keywords: radiomics; prostate cancer; statin; omega-3; artificial intelligence; MRI radiomics; prostate cancer; statin; omega-3; artificial intelligence; MRI

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MDPI and ACS Style

Shi, Y.; Wahle, E.; Du, Q.; Krajewski, L.; Liang, X.; Zhou, S.; Zhang, C.; Baine, M.; Zheng, D. Associations between Statin/Omega3 Usage and MRI-Based Radiomics Signatures in Prostate Cancer. Diagnostics 2021, 11, 85. https://doi.org/10.3390/diagnostics11010085

AMA Style

Shi Y, Wahle E, Du Q, Krajewski L, Liang X, Zhou S, Zhang C, Baine M, Zheng D. Associations between Statin/Omega3 Usage and MRI-Based Radiomics Signatures in Prostate Cancer. Diagnostics. 2021; 11(1):85. https://doi.org/10.3390/diagnostics11010085

Chicago/Turabian Style

Shi, Yu, Ethan Wahle, Qian Du, Luke Krajewski, Xiaoying Liang, Sumin Zhou, Chi Zhang, Michael Baine, and Dandan Zheng. 2021. "Associations between Statin/Omega3 Usage and MRI-Based Radiomics Signatures in Prostate Cancer" Diagnostics 11, no. 1: 85. https://doi.org/10.3390/diagnostics11010085

APA Style

Shi, Y., Wahle, E., Du, Q., Krajewski, L., Liang, X., Zhou, S., Zhang, C., Baine, M., & Zheng, D. (2021). Associations between Statin/Omega3 Usage and MRI-Based Radiomics Signatures in Prostate Cancer. Diagnostics, 11(1), 85. https://doi.org/10.3390/diagnostics11010085

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