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Article

Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine

1
Department of Pulmonology, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 300041 Timişoara, Romania
2
CardioPrevent Foundation, 3 Calea Dorobanţilor, 300134 Timişoara, Romania
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Department I—Drug Analysis, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Sq., 300041 Timişoara, Romania
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Department of Computer and Information Technology, University Politehnica of Timişoara, 2 Vasile Pârvan Blvd., 300223 Timişoara, Romania
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Timişoara Institute of Complex Systems, 18 Vasile Lucaciu Str., 300044 Timişoara, Romania
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Department of Cardiology, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 300041 Timişoara, Romania
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(1), 86; https://doi.org/10.3390/diagnostics11010086
Received: 9 December 2020 / Revised: 30 December 2020 / Accepted: 5 January 2021 / Published: 7 January 2021
(This article belongs to the Special Issue Diagnosis and Management of Obstructive Sleep Apnea)
We explored the relationship between obstructive sleep apnea (OSA) patients’ anthropometric measures and the CPAP treatment response. To that end, we processed three non-overlapping cohorts (D1, D2, D3) with 1046 patients from four sleep laboratories in Western Romania, including 145 subjects (D1) with one-night CPAP therapy. Using D1 data, we created a CPAP-response network of patients, and found neck circumference (NC) as the most significant qualitative indicator for apnea–hypopnea index (AHI) improvement. We also investigated a quantitative NC cutoff value for OSA screening on cohorts D2 (OSA-diagnosed) and D3 (control), using the area under the curve. As such, we confirmed the correlation between NC and AHI (ρ=0.35, p<0.001) and showed that 71% of diagnosed male subjects had bigger NC values than subjects with no OSA (area under the curve is 0.71, with 95% CI 0.63–0.79, p<0.001); the optimal NC cutoff is 41 cm, with a sensitivity of 0.8099, a specificity of 0.5185, positive predicted value (PPV) = 0.9588, negative predicted value (NPV) = 0.1647, and positive likelihood ratio (LR+) = 1.68. Our NC =41 cm threshold classified the D1 patients’ CPAP responses—measured as the difference in AHI prior to and after the one-night use of CPAP—with a sensitivity of 0.913 and a specificity of 0.859. View Full-Text
Keywords: network medicine; obstructive sleep apnea syndrome; CPAP treatment response; anthropometric measures network medicine; obstructive sleep apnea syndrome; CPAP treatment response; anthropometric measures
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MDPI and ACS Style

Mihaicuta, S.; Udrescu, L.; Udrescu, M.; Toth, I.-A.; Topîrceanu, A.; Pleavă, R.; Ardelean, C. Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine. Diagnostics 2021, 11, 86. https://doi.org/10.3390/diagnostics11010086

AMA Style

Mihaicuta S, Udrescu L, Udrescu M, Toth I-A, Topîrceanu A, Pleavă R, Ardelean C. Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine. Diagnostics. 2021; 11(1):86. https://doi.org/10.3390/diagnostics11010086

Chicago/Turabian Style

Mihaicuta, Stefan, Lucreţia Udrescu, Mihai Udrescu, Izabella-Anita Toth, Alexandru Topîrceanu, Roxana Pleavă, and Carmen Ardelean. 2021. "Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine" Diagnostics 11, no. 1: 86. https://doi.org/10.3390/diagnostics11010086

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