Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine

Mihaicuta, Stefan; Udrescu, Lucreţia; Udrescu, Mihai; Toth, Izabella-Anita; Topîrceanu, Alexandru; Pleavă, Roxana; Ardelean, Carmen

doi:10.3390/diagnostics11010086

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Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine

^1,2

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¹,

⁴

⁶ and

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Department of Pulmonology, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 300041 Timişoara, Romania

CardioPrevent Foundation, 3 Calea Dorobanţilor, 300134 Timişoara, Romania

Department I—Drug Analysis, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Sq., 300041 Timişoara, Romania

⁴

Department of Computer and Information Technology, University Politehnica of Timişoara, 2 Vasile Pârvan Blvd., 300223 Timişoara, Romania

⁵

Timişoara Institute of Complex Systems, 18 Vasile Lucaciu Str., 300044 Timişoara, Romania

⁶

Department of Cardiology, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 300041 Timişoara, Romania

Author to whom correspondence should be addressed.

Diagnostics 2021, 11(1), 86; https://doi.org/10.3390/diagnostics11010086

Received: 9 December 2020 / Revised: 30 December 2020 / Accepted: 5 January 2021 / Published: 7 January 2021

(This article belongs to the Special Issue Diagnosis and Management of Obstructive Sleep Apnea)

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Abstract

We explored the relationship between obstructive sleep apnea (OSA) patients’ anthropometric measures and the CPAP treatment response. To that end, we processed three non-overlapping cohorts (

D_{1}

D_{2}

D_{3}

) with 1046 patients from four sleep laboratories in Western Romania, including 145 subjects (

D_{1}

) with one-night CPAP therapy. Using

D_{1}

data, we created a CPAP-response network of patients, and found neck circumference (NC) as the most significant qualitative indicator for apnea–hypopnea index (AHI) improvement. We also investigated a quantitative NC cutoff value for OSA screening on cohorts

D_{2}

(OSA-diagnosed) and

D_{3}

(control), using the area under the curve. As such, we confirmed the correlation between NC and AHI (

ρ = 0.35

p < 0.001

) and showed that 71% of diagnosed male subjects had bigger NC values than subjects with no OSA (area under the curve is 0.71, with 95% CI 0.63–0.79,

p < 0.001

); the optimal NC cutoff is 41 cm, with a sensitivity of 0.8099, a specificity of 0.5185, positive predicted value (PPV) = 0.9588, negative predicted value (NPV) = 0.1647, and positive likelihood ratio (LR+) = 1.68. Our NC

= 41

cm threshold classified the

D_{1}

patients’ CPAP responses—measured as the difference in AHI prior to and after the one-night use of CPAP—with a sensitivity of 0.913 and a specificity of 0.859. View Full-Text

Keywords: network medicine; obstructive sleep apnea syndrome; CPAP treatment response; anthropometric measures

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Mihaicuta, S.; Udrescu, L.; Udrescu, M.; Toth, I.-A.; Topîrceanu, A.; Pleavă, R.; Ardelean, C. Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine. Diagnostics 2021, 11, 86. https://doi.org/10.3390/diagnostics11010086

AMA Style

Mihaicuta S, Udrescu L, Udrescu M, Toth I-A, Topîrceanu A, Pleavă R, Ardelean C. Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine. Diagnostics. 2021; 11(1):86. https://doi.org/10.3390/diagnostics11010086

Chicago/Turabian Style

Mihaicuta, Stefan, Lucreţia Udrescu, Mihai Udrescu, Izabella-Anita Toth, Alexandru Topîrceanu, Roxana Pleavă, and Carmen Ardelean. 2021. "Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine" Diagnostics 11, no. 1: 86. https://doi.org/10.3390/diagnostics11010086

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