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Diagnostic Accuracy of FibroScan and Factors Affecting Measurements

1
Liver Center, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8501, Japan
2
Department of Laboratory Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8501, Japan
3
Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
4
Department of Clinical Laboratory Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(11), 940; https://doi.org/10.3390/diagnostics10110940
Received: 8 September 2020 / Revised: 10 November 2020 / Accepted: 11 November 2020 / Published: 12 November 2020
(This article belongs to the Special Issue Fatty Liver Disease: Diagnostic, Predictive and Prognostic Markers)
Evaluating liver steatosis and fibrosis is important for patients with non-alcoholic fatty liver disease. Although liver biopsy and pathological assessment is the gold standard for these conditions, this technique has several disadvantages. The evaluation of steatosis and fibrosis using ultrasound B-mode imaging is qualitative and subjective. The liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) determined using FibroScan are the evidence-based non-invasive measures of liver fibrosis and steatosis, respectively. The LSM and CAP measurements are carried out simultaneously, and the median values of more than ten valid measurements are used to quantify liver fibrosis and steatosis. Here, we demonstrate that the reliability of the LSM depends on the interquartile range to median ratio (IQR/Med), but CAP values do not depend on IQR/Med. In addition, the LSM is affected by inflammation, congestion, and cholestasis in addition to fibrosis, while CAP values are affected by the body mass index in addition to steatosis. We also show that the M probe provides higher LSM values but lower CAP values than the XL probe in the same population. However, there was no statistically significant difference between the diagnostic accuracies of the two probes. These findings are important to understand the reliability of FibroScan measurements and the factors influencing measurement values for all patients. View Full-Text
Keywords: non-alcoholic fatty liver disease; hepatic steatosis; hepatic inflammation; transient elastography; liver stiffness measurement; controlled attenuation parameter non-alcoholic fatty liver disease; hepatic steatosis; hepatic inflammation; transient elastography; liver stiffness measurement; controlled attenuation parameter
MDPI and ACS Style

Oeda, S.; Tanaka, K.; Oshima, A.; Matsumoto, Y.; Sueoka, E.; Takahashi, H. Diagnostic Accuracy of FibroScan and Factors Affecting Measurements. Diagnostics 2020, 10, 940. https://doi.org/10.3390/diagnostics10110940

AMA Style

Oeda S, Tanaka K, Oshima A, Matsumoto Y, Sueoka E, Takahashi H. Diagnostic Accuracy of FibroScan and Factors Affecting Measurements. Diagnostics. 2020; 10(11):940. https://doi.org/10.3390/diagnostics10110940

Chicago/Turabian Style

Oeda, Satoshi; Tanaka, Kenichi; Oshima, Ayaka; Matsumoto, Yasue; Sueoka, Eisaburo; Takahashi, Hirokazu. 2020. "Diagnostic Accuracy of FibroScan and Factors Affecting Measurements" Diagnostics 10, no. 11: 940. https://doi.org/10.3390/diagnostics10110940

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