Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Varied Lipid Combinations Elicit Discrete Dynamic Profiles of Self-Assembly
3.2. Exit Rates of Lipids from Pre-Micelles Are Significantly Affected by Compositional Variation
3.3. Entry Rates of Lipids into Pre-Micelles Show Sensitivity to Compositional Variation
3.4. Specific Headgroup Interactions Contribute to Observed Rate Modifications
3.5. Observed Accretion Kinetics Predicts Micelle Self-Reproduction at Non-Random Compositions
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Ratio | Monomer Count | |
---|---|---|
1 | 10%/90% | 6/48 |
2 | 30%/70% | 16/38 |
3 | 50%/50% | 27/27 |
4 | 70%/30% | 38/16 |
5 | 90%/10% | 48/6 |
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Kahana, A.; Lancet, D.; Palmai, Z. Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction. Life 2022, 12, 955. https://doi.org/10.3390/life12070955
Kahana A, Lancet D, Palmai Z. Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction. Life. 2022; 12(7):955. https://doi.org/10.3390/life12070955
Chicago/Turabian StyleKahana, Amit, Doron Lancet, and Zoltan Palmai. 2022. "Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction" Life 12, no. 7: 955. https://doi.org/10.3390/life12070955