Next Article in Journal
Perception of Thermal Comfort during Skin Cooling and Heating
Next Article in Special Issue
Body Mass Index Influence for the Personalization of the Monoclonal Antibodies Therapy for Psoriasis
Previous Article in Journal
How Was Nature Able to Discover Its Own Laws—Twice?
Previous Article in Special Issue
Blue Light in Dermatology
 
 
Review

Hippo Signaling Pathway as a New Potential Target in Non-Melanoma Skin Cancers: A Narrative Review

1
Department of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Lodz, 91-347 Lodz, Poland
2
Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, 93-513 Lodz, Poland
3
Laboratory of Molecular Biology, VET-LAB Brudzew, 62-720 Brudzew, Poland
4
Department of Clinical Genetics, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Chang-Hun Huh
Life 2021, 11(7), 680; https://doi.org/10.3390/life11070680
Received: 23 June 2021 / Revised: 5 July 2021 / Accepted: 8 July 2021 / Published: 12 July 2021
(This article belongs to the Special Issue Frontiers of Dermatological Research)
Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), are the most frequently diagnosed cancers in humans, however, their exact pathogenesis is not fully understood. In recent years, it has been hypothesized that the recently discovered Hippo pathway could play a detrimental role in cutaneous carcinogenesis, but no direct connections have been made. The Hippo pathway and its effector, YAP, are responsible for tissue growth by accelerating cell proliferation, however, YAP upregulation and overexpression have also been reported in numerous types of tumors. There is also evidence that disrupted YAP/Hippo signaling is responsible for cancer growth, invasion, and metastasis. In this short review, we will explore whether the Hippo pathway is an important regulator of skin carcinogenesis and if it could be a promising target for future therapies. View Full-Text
Keywords: Hippo signaling; basal cell carcinoma; squamous cell carcinoma; YAP Hippo signaling; basal cell carcinoma; squamous cell carcinoma; YAP
Show Figures

Figure 1

MDPI and ACS Style

Bednarski, I.A.; Ciążyńska, M.; Wódz, K.; Dróżdż, I.; Skibińska, M.; Narbutt, J.; Lesiak, A. Hippo Signaling Pathway as a New Potential Target in Non-Melanoma Skin Cancers: A Narrative Review. Life 2021, 11, 680. https://doi.org/10.3390/life11070680

AMA Style

Bednarski IA, Ciążyńska M, Wódz K, Dróżdż I, Skibińska M, Narbutt J, Lesiak A. Hippo Signaling Pathway as a New Potential Target in Non-Melanoma Skin Cancers: A Narrative Review. Life. 2021; 11(7):680. https://doi.org/10.3390/life11070680

Chicago/Turabian Style

Bednarski, Igor Aleksander, Magdalena Ciążyńska, Karolina Wódz, Izabela Dróżdż, Małgorzata Skibińska, Joanna Narbutt, and Aleksandra Lesiak. 2021. "Hippo Signaling Pathway as a New Potential Target in Non-Melanoma Skin Cancers: A Narrative Review" Life 11, no. 7: 680. https://doi.org/10.3390/life11070680

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop