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Antibodies, Volume 8, Issue 2

June 2019 - 13 articles

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Articles (13)

  • Review
  • Open Access
185 Citations
25,138 Views
31 Pages

Since the licensing of the first monoclonal antibody therapy in 1986, monoclonal antibodies have become the largest class of biopharmaceuticals with over 80 antibodies currently approved for a variety of disease indications. The development of smalle...

  • Review
  • Open Access
48 Citations
10,010 Views
25 Pages

Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases

  • Kasandra Bélanger,
  • Umar Iqbal,
  • Jamshid Tanha,
  • Roger MacKenzie,
  • Maria Moreno and
  • Danica Stanimirovic

Antibodies have become one of the most successful therapeutics for a number of oncology and inflammatory diseases. So far, central nervous system (CNS) indications have missed out on the antibody revolution, while they remain ‘hidden’ beh...

  • Article
  • Open Access
31 Citations
9,625 Views
13 Pages

VHH-Photosensitizer Conjugates for Targeted Photodynamic Therapy of Met-Overexpressing Tumor Cells

  • Raimond Heukers,
  • Vida Mashayekhi,
  • Mercedes Ramirez-Escudero,
  • Hans de Haard,
  • Theo C. Verrips,
  • Paul. M.P. van Bergen en Henegouwen and
  • Sabrina Oliveira

Photodynamic therapy (PDT) is an approach that kills (cancer) cells by the local production of toxic reactive oxygen species upon the local illumination of a photosensitizer (PS). The specificity of PDT has been further enhanced by the development of...

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Antibodies - ISSN 2073-4468