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Genes 2018, 9(8), 404; https://doi.org/10.3390/genes9080404

Membrane-Associated Proteins in Giardia lamblia

Instituto de Investigación Médica Mercedes y Martín Ferreyra—INIMEC-CONICET—Universidad Nacional de Córdoba, Friuli 2434, Córdoba 5000, Argentina
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Received: 17 July 2018 / Revised: 3 August 2018 / Accepted: 7 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue Membrane Proteins in Parasitic Protozoa)
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Abstract

The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other proteins or enzymes. Understanding these properties may help to define the function of a protein and also the role of an organelle. In the case of microorganisms like protozoa parasites, it may help to understand singular features that will eventually lead to the design of parasite-specific drugs. The protozoa parasite Giardia lamblia is an example of a widespread parasite that has been infecting humans and animals from ancestral times, adjusting itself to the changes of the environment inside and outside the host. Several membrane-associated proteins have been posted in the genome database GiardiaDB, although only a few of them have been characterized. This review discusses the data regarding membrane-associated proteins in relationship with lipids and specific organelles and their implication in the discovery of anti-giardial therapies. View Full-Text
Keywords: PX domain; variant-specific surface protein; palmitoylation; phosphoinositides; lysosomal vacuoles PX domain; variant-specific surface protein; palmitoylation; phosphoinositides; lysosomal vacuoles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Touz, M.C.; Feliziani, C.; Rópolo, A.S. Membrane-Associated Proteins in Giardia lamblia. Genes 2018, 9, 404.

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