Next Article in Journal
Mitotic Recombination and Adaptive Genomic Changes in Human Pathogenic Fungi
Next Article in Special Issue
Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma
Previous Article in Journal
NOP53 as A Candidate Modifier Locus for Familial Non-Medullary Thyroid Cancer
Previous Article in Special Issue
Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis
Open AccessReview

Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer

Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
*
Author to whom correspondence should be addressed.
Genes 2019, 10(11), 900; https://doi.org/10.3390/genes10110900
Received: 13 September 2019 / Revised: 31 October 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Animal Modeling in Cancer)
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Mouse models are a valuable resource for use throughout the development and testing of new therapeutic strategies for CRC. Tumorigenesis and response to therapy in humans and mouse models alike are influenced by the microbial communities that colonize the gut. Differences in the composition of the gut microbiota can confound experimental findings and reduce the replicability and translatability of the resulting data. Despite this, the contribution of resident microbiota to preclinical tumor models is often underappreciated. This review does the following: (1) summarizes evidence that the gut microbiota influence CRC disease phenotypes; (2) outlines factors that can influence the composition of the gut microbiota; and (3) provides strategies that can be incorporated into the experimental design, to account for the influence of the microbiota on intestinal phenotypes in mouse models of CRC. Through careful experimental design and documentation, mouse models can continue to rapidly advance efforts to prevent and treat colon cancer. View Full-Text
Keywords: colorectal cancer; mouse models; microbiota; antitumor immunity colorectal cancer; mouse models; microbiota; antitumor immunity
Show Figures

Figure 1

MDPI and ACS Style

Leystra, A.A.; Clapper, M.L. Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer. Genes 2019, 10, 900.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop