Next Article in Journal
Testosterone Degradative Pathway of Novosphingobium tardaugens
Previous Article in Journal
Nuclear–Cytoplasmic Coevolution Analysis of RuBisCO in Synthesized Cucumis Allopolyploid
Previous Article in Special Issue
The Biochemical Activities of the Saccharomyces cerevisiae Pif1 Helicase Are Regulated by Its N-Terminal Domain
Open AccessReview

Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo

1
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada
2
Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada
3
European Research Institute for the Biology of Ageing, University of Groningen, 9713 AV Groningen, The Netherlands
4
Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Genes 2019, 10(11), 870; https://doi.org/10.3390/genes10110870
Received: 14 October 2019 / Revised: 29 October 2019 / Accepted: 29 October 2019 / Published: 31 October 2019
(This article belongs to the Special Issue DNA Helicases: Mechanisms, Biological Pathways, and Disease Relevance)
Guanine quadruplex (G4) structures are among the most stable secondary DNA structures that can form in vitro, and evidence for their existence in vivo has been steadily accumulating. Originally described mainly for their deleterious effects on genome stability, more recent research has focused on (potential) functions of G4 structures in telomere maintenance, gene expression, and other cellular processes. The combined research on G4 structures has revealed that properly regulating G4 DNA structures in cells is important to prevent genome instability and disruption of normal cell function. In this short review we provide some background and historical context of our work resulting in the identification of FANCJ, RTEL1 and BLM as helicases that act on G4 structures in vivo. Taken together these studies highlight important roles of different G4 DNA structures and specific G4 helicases at selected genomic locations and telomeres in regulating gene expression and maintaining genome stability. View Full-Text
Keywords: Guanine quadruplex (G4) DNA structures; G4 helicases; DOG-1; FANCJ; RTEL1; BLM; sister chromatid exchange events (SCEs); genomic mapping of SCEs; molecular phenotype; single cell Strand-seq Guanine quadruplex (G4) DNA structures; G4 helicases; DOG-1; FANCJ; RTEL1; BLM; sister chromatid exchange events (SCEs); genomic mapping of SCEs; molecular phenotype; single cell Strand-seq
Show Figures

Figure 1

MDPI and ACS Style

Lansdorp, P.; van Wietmarschen, N. Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo. Genes 2019, 10, 870.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop