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To Repeat or Not to Repeat: Repetitive Sequences Regulate Genome Stability in Candida albicans

1
Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA
2
Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Genes 2019, 10(11), 866; https://doi.org/10.3390/genes10110866
Received: 30 September 2019 / Revised: 15 October 2019 / Accepted: 23 October 2019 / Published: 30 October 2019
(This article belongs to the Special Issue Genome plasticity of human and plant pathogenic fungi)
Genome instability often leads to cell death but can also give rise to innovative genotypic and phenotypic variation through mutation and structural rearrangements. Repetitive sequences and chromatin architecture in particular are critical modulators of recombination and mutability. In Candida albicans, four major classes of repeats exist in the genome: telomeres, subtelomeres, the major repeat sequence (MRS), and the ribosomal DNA (rDNA) locus. Characterization of these loci has revealed how their structure contributes to recombination and either promotes or restricts sequence evolution. The mechanisms of recombination that give rise to genome instability are known for some of these regions, whereas others are generally unexplored. More recent work has revealed additional repetitive elements, including expanded gene families and centromeric repeats that facilitate recombination and genetic innovation. Together, the repeats facilitate C. albicans evolution through construction of novel genotypes that underlie C. albicans adaptive potential and promote persistence across its human host. View Full-Text
Keywords: genome stability, telomere, subtelomere, gene family expansion, LTR, MRS, Candida albicans genome stability, telomere, subtelomere, gene family expansion, LTR, MRS, Candida albicans
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Dunn, M.J.; Anderson, M.Z. To Repeat or Not to Repeat: Repetitive Sequences Regulate Genome Stability in Candida albicans. Genes 2019, 10, 866.

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