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Review

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

Department of Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland
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Author to whom correspondence should be addressed.
Cells 2020, 9(8), 1877; https://doi.org/10.3390/cells9081877
Received: 2 July 2020 / Revised: 4 August 2020 / Accepted: 9 August 2020 / Published: 11 August 2020
(This article belongs to the Special Issue Scavenger Receptor Structure and Function in Health and Disease)
CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes cells sensitive to metabolic abnormalities associated with metabolic syndrome and diabetes mellitus (DM), such as monocytes and macrophages, epithelial cells, adipocytes, hepatocytes, skeletal and cardiac myocytes, pancreatic β-cells, kidney glomeruli and tubules cells, pericytes and pigment epithelium cells of the retina, and Schwann cells. These features make CD36 an important component of the pathogenesis of DM and its complications, but also a promising target in the treatment of these disorders. The detrimental effects of CD36 signaling are mediated by the uptake of fatty acids and modified lipoproteins, deposition of lipids and their lipotoxicity, alterations in insulin response and the utilization of energy substrates, oxidative stress, inflammation, apoptosis, and fibrosis leading to the progressive, often irreversible organ dysfunction. This review summarizes the extensive knowledge of the contribution of CD36 to DM and its complications, including nephropathy, retinopathy, peripheral neuropathy, and cardiomyopathy. View Full-Text
Keywords: cardiomyopathy; hyperglycemia; fatty acids; inflammation; insulin resistance; lipotoxicity; nephropathy; neuropathy; oxidative stress; retinopathy cardiomyopathy; hyperglycemia; fatty acids; inflammation; insulin resistance; lipotoxicity; nephropathy; neuropathy; oxidative stress; retinopathy
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MDPI and ACS Style

Puchałowicz, K.; Rać, M.E. The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring. Cells 2020, 9, 1877. https://doi.org/10.3390/cells9081877

AMA Style

Puchałowicz K, Rać ME. The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring. Cells. 2020; 9(8):1877. https://doi.org/10.3390/cells9081877

Chicago/Turabian Style

Puchałowicz, Kamila, and Monika E. Rać 2020. "The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring" Cells 9, no. 8: 1877. https://doi.org/10.3390/cells9081877

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