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Article

A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death

1
Laboratory of Molecular immunogenetics of cancer, Institute of gene biology RAS, Vavilova 34/5, 111394 Moscow, Russia
2
Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Prospect Nauki 6, 142290 Pushchino, Russia
3
Laboratory of bioengineering of neuromodulators and neuroreceptors, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklucho-Maklaya str., 16/10, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Cells 2020, 9(2), 488; https://doi.org/10.3390/cells9020488
Received: 27 January 2020 / Revised: 14 February 2020 / Accepted: 19 February 2020 / Published: 20 February 2020
(This article belongs to the Special Issue Molecular Chaperones: Cancer and Cell Death)
Investigation of interactions between a pro-inflammatory cytokine tumor necrosis factor (TNFα) and its receptor is required for the development of new treatments for autoimmune diseases associated with the adverse effects of TNFα. Earlier, we demonstrated that the innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. In this study, we show that a 12-mer peptide, designated 17.1, which was derived from the Tag7 protein, can be regarded as a novel TNFα inhibitor, also is able to form a cytotoxic complex with the heat shock protein Hsp70. This finding demonstrates a new role for Hsp70 protein in the immune response. Also, this new inhibitory 17.1 peptide demonstrates an anti-inflammatory activity in the complete Freund’s adjuvant (CFA)-induced autoimmune arthritis model in laboratory mice. It appears that the 17.1 peptide could potentially be used as an anti-inflammatory agent. View Full-Text
Keywords: Hsp70; Tag7; TNFR1; apoptosis; necroptosis; rheumatoid arthritis; peptides Hsp70; Tag7; TNFR1; apoptosis; necroptosis; rheumatoid arthritis; peptides
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MDPI and ACS Style

Romanova, E.A.; Sharapova, T.N.; Telegin, G.B.; Minakov, A.N.; Chernov, A.S.; Ivanova, O.K.; Bychkov, M.L.; Sashchenko, L.P.; Yashin, D.V. A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death. Cells 2020, 9, 488. https://doi.org/10.3390/cells9020488

AMA Style

Romanova EA, Sharapova TN, Telegin GB, Minakov AN, Chernov AS, Ivanova OK, Bychkov ML, Sashchenko LP, Yashin DV. A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death. Cells. 2020; 9(2):488. https://doi.org/10.3390/cells9020488

Chicago/Turabian Style

Romanova, Elena A., Tatiana N. Sharapova, Georgii B. Telegin, Alexei N. Minakov, Alexander S. Chernov, Olga K. Ivanova, Maxim L. Bychkov, Lidia P. Sashchenko, and Denis V. Yashin 2020. "A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death" Cells 9, no. 2: 488. https://doi.org/10.3390/cells9020488

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