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Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

1
Department of Oncogenomics, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
2
Department of Physiology, Faculty of Medicine and Dentistry. University of Valencia-INCLIVA, 46010 Valencia, Spain
3
CIBER de Enfermedades Raras (CIBERER), 46010 Valencia, Spain
4
Associated Unit for Rare Diseases INCLIVA-CIPF, 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
Cells 2020, 9(2), 358; https://doi.org/10.3390/cells9020358
Received: 10 December 2019 / Revised: 27 January 2020 / Accepted: 29 January 2020 / Published: 4 February 2020
(This article belongs to the Special Issue Frontiers in Cytoskeleton Research—From Development to Disease)
Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the molecular mechanisms underlying neurological diseases and allow us to see beyond our current knowledge for the development of new treatments. The neuronal cytoskeleton can be described as an organelle formed by the three-dimensional lattice of the three main families of filaments: actin filaments, microtubules, and neurofilaments. This organelle organizes well-defined structures within neurons (cell bodies and axons), which allow their proper development and function through life. Here, we will provide an overview of both the basic and novel concepts related to those cytoskeletal proteins, which are emerging as potential targets in the study of the pathophysiological mechanisms underlying neurological disorders.
Keywords: actin; tubulin; neurofilaments; microtubules; neuron; growth cone; cytoskeleton; neurological diseases actin; tubulin; neurofilaments; microtubules; neuron; growth cone; cytoskeleton; neurological diseases
MDPI and ACS Style

Muñoz-Lasso, D.C.; Romá-Mateo, C.; Pallardó, F.V.; Gonzalez-Cabo, P. Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders. Cells 2020, 9, 358.

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