Next Article in Journal
Red LED Light Acts on the Mitochondrial Electron Chain of Mammalian Sperm via Light-Time Exposure-Dependent Mechanisms
Previous Article in Journal
Cnidarian Cell Cryopreservation: A Powerful Tool for Cultivation and Functional Assays
Previous Article in Special Issue
A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?
Review

Systematic Review of Stem-Cell-Based Therapy of Burn Wounds: Lessons Learned from Animal and Clinical Studies

1
Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, 9220 Aalborg, Denmark
2
Regenerative Medicine Group, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 3B, 9220 Aalborg, Denmark
*
Author to whom correspondence should be addressed.
Cells 2020, 9(12), 2545; https://doi.org/10.3390/cells9122545
Received: 22 October 2020 / Revised: 18 November 2020 / Accepted: 24 November 2020 / Published: 26 November 2020
(This article belongs to the Special Issue Stem Cell Therapy: Wound Healing and Skin Regeneration)
Treatment of severe burn wounds presents a daunting medical challenge, and novel approaches promoting healing and reducing scarring are highly desirable. The application of mesenchymal stem/stromal cells (MSCs) has been suggested as a novel treatment. In this paper, we present systematic reviews of pre-clinical and clinical studies of MSC therapy for second- or third-degree thermal burn wounds. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, the PubMed and Embase databases were searched, and interventional studies of MSC therapy using rodent models (21 studies) or human burn patients (three studies) were included in the pre-clinical and clinical reviews, respectively, where both overall outcome and wound-healing-phase-specific methodologies and effects were assessed. The pre-clinical studies demonstrated a promising effect of the application of MSCs on several wound healing phases. The clinical studies also suggested that the MSC treatment was beneficial, particularly in the remodeling phase. However, the limited number of studies, their lack of homogeneity in study design, relatively high risk of bias, lack of reporting on mode of action (MOA), and discontinuity of evidence restrict the strength of these findings. This comprehensive review presents an overview of available methodologies to assess the MOA of MSC treatment for distinct wound healing phases. Furthermore, it includes a set of recommendations for the design of high-quality clinical studies that can determine the efficacy of MSCs as a therapy for burn wounds. View Full-Text
Keywords: burn wound; mesenchymal stem cell; stem-cell-based treatment; adipose-derived stem cells; ASC; MSC burn wound; mesenchymal stem cell; stem-cell-based treatment; adipose-derived stem cells; ASC; MSC
Show Figures

Graphical abstract

MDPI and ACS Style

Henriksen, J.L.; Sørensen, N.B.; Fink, T.; Zachar, V.; Porsborg, S.R. Systematic Review of Stem-Cell-Based Therapy of Burn Wounds: Lessons Learned from Animal and Clinical Studies. Cells 2020, 9, 2545. https://doi.org/10.3390/cells9122545

AMA Style

Henriksen JL, Sørensen NB, Fink T, Zachar V, Porsborg SR. Systematic Review of Stem-Cell-Based Therapy of Burn Wounds: Lessons Learned from Animal and Clinical Studies. Cells. 2020; 9(12):2545. https://doi.org/10.3390/cells9122545

Chicago/Turabian Style

Henriksen, Josefine L., Nana B. Sørensen, Trine Fink, Vladimir Zachar, and Simone R. Porsborg 2020. "Systematic Review of Stem-Cell-Based Therapy of Burn Wounds: Lessons Learned from Animal and Clinical Studies" Cells 9, no. 12: 2545. https://doi.org/10.3390/cells9122545

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop