Next Article in Journal
Insulin-Like Growth Factors in Development, Cancers and Aging
Previous Article in Journal
GUN1 and Plastid RNA Metabolism: Learning from Genetics
Previous Article in Special Issue
Breast Cancer Subtypes Underlying EMT-Mediated Catabolic Metabolism
Open AccessReview

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
Cells 2020, 9(10), 2308; https://doi.org/10.3390/cells9102308 (registering DOI)
Received: 14 September 2020 / Revised: 10 October 2020 / Accepted: 13 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue New Aspects of Targeting Cancer Metabolism in Therapeutic Approach)
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, and cancer stem cells. Well-known oncogenic signaling pathways, such as phosphoinositide 3-kinase (PI3K)/AKT, Myc, and Hippo pathway, mediate metabolic gene expression and increase metabolic enzyme activities. Vice versa, deregulated metabolic pathways contribute to defects in cellular signal transduction pathways, which in turn provide energy, building blocks, and redox potentials for unrestrained cancer cell proliferation. Studies and clinical trials are being performed that focus on the inhibition of metabolic enzymes by small molecules or dietary interventions (e.g., fasting, calorie restriction, and intermittent fasting). Similar to genetic heterogeneity, the metabolic phenotypes of cancers are highly heterogeneous. This heterogeneity results from diverse cues in the tumor microenvironment and genetic mutations. Hence, overcoming metabolic plasticity is an important goal of modern cancer therapeutics. This review highlights recent findings on the metabolic phenotypes of cancer and elucidates the interactions between signal transduction pathways and metabolic pathways. We also provide novel rationales for designing the next-generation cancer metabolism drugs. View Full-Text
Keywords: cancer metabolism; cell signaling; drug development; metabolic plasticity cancer metabolism; cell signaling; drug development; metabolic plasticity
Show Figures

Figure 1

MDPI and ACS Style

Park, J.H.; Pyun, W.Y.; Park, H.W. Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets. Cells 2020, 9, 2308.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop