Next Article in Journal
Use of a Hybrid Adeno-Associated Viral Vector Transposon System to Deliver the Insulin Gene to Diabetic NOD Mice
Next Article in Special Issue
The Multi-Omics Architecture of Juvenile Idiopathic Arthritis
Previous Article in Journal
The Functioning of Na+-ATPases from Protozoan Parasites: Are These Pumps Targets for Antiparasitic Drugs?
Previous Article in Special Issue
Small Molecule Inhibitors in the Treatment of Rheumatoid Arthritis and Beyond: Latest Updates and Potential Strategy for Fighting COVID-19
Review

Intrathymic Selection and Defects in the Thymic Epithelial Cell Development

1
Department of Cell Biology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain
2
Health Research Institute, Hospital 12 de Octubre (imas12), 28041 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contribute equally to the article.
Cells 2020, 9(10), 2226; https://doi.org/10.3390/cells9102226
Received: 7 September 2020 / Revised: 29 September 2020 / Accepted: 30 September 2020 / Published: 2 October 2020
(This article belongs to the Special Issue Molecular and Cellular Basis of Autoimmune Diseases)
Intimate interactions between thymic epithelial cells (TECs) and thymocytes (T) have been repeatedly reported as essential for performing intrathymic T-cell education. Nevertheless, it has been described that animals exhibiting defects in these interactions were capable of a proper positive and negative T-cell selection. In the current review, we first examined distinct types of TECs and their possible role in the immune surveillance. However, EphB-deficient thymi that exhibit profound thymic epithelial (TE) alterations do not exhibit important immunological defects. Eph and their ligands, the ephrins, are implicated in cell attachment/detachment and govern, therefore, TEC–T interactions. On this basis, we hypothesized that a few normal TE areas could be enough for a proper phenotypical and functional maturation of T lymphocytes. Then, we evaluated in vivo how many TECs would be necessary for supporting a normal T-cell differentiation, concluding that a significantly low number of TEC are still capable of supporting normal T lymphocyte maturation, whereas with fewer numbers, T-cell maturation is not possible. View Full-Text
Keywords: thymic epithelial cells; thymocyte education; regulatory T-cells; Eph/ephrins thymic epithelial cells; thymocyte education; regulatory T-cells; Eph/ephrins
Show Figures

Graphical abstract

MDPI and ACS Style

García-Ceca, J.; Montero-Herradón, S.; Zapata, A.G. Intrathymic Selection and Defects in the Thymic Epithelial Cell Development. Cells 2020, 9, 2226. https://doi.org/10.3390/cells9102226

AMA Style

García-Ceca J, Montero-Herradón S, Zapata AG. Intrathymic Selection and Defects in the Thymic Epithelial Cell Development. Cells. 2020; 9(10):2226. https://doi.org/10.3390/cells9102226

Chicago/Turabian Style

García-Ceca, Javier, Sara Montero-Herradón, and Agustín G. Zapata 2020. "Intrathymic Selection and Defects in the Thymic Epithelial Cell Development" Cells 9, no. 10: 2226. https://doi.org/10.3390/cells9102226

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop