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Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis

1
Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
2
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
*
Authors to whom correspondence should be addressed.
Cells 2019, 8(6), 544; https://doi.org/10.3390/cells8060544
Received: 14 May 2019 / Revised: 31 May 2019 / Accepted: 1 June 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Angiogenesis in Cancer)
Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development, emerging evidence indicates that tumor microenvironment-mediated changes in glycosylation play a crucial functional role in tumor progression and metastasis. Hypoxia and inflammatory events regulate protein glycosylation in tumor cells and associated stromal cells in the tumor microenvironment, which facilitates tumor progression and also modulates a patient’s response to anti-cancer therapeutics. In this review, we highlight the impact of altered glycosylation on angiogenic signaling and endothelial cell adhesion, and the critical consequences of these changes in tumor behavior. View Full-Text
Keywords: glycosylation; tumor microenvironment; angiogenesis; metastasis; N-glycosylation; O-glycosylation; glycosaminoglycans; endothelial; hypoxia; inflammation glycosylation; tumor microenvironment; angiogenesis; metastasis; N-glycosylation; O-glycosylation; glycosaminoglycans; endothelial; hypoxia; inflammation
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MDPI and ACS Style

Brown Chandler, K.; E. Costello, C.; Rahimi, N. Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis. Cells 2019, 8, 544.

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