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Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer

1
Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA
2
Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 394; https://doi.org/10.3390/cells8050394
Received: 21 March 2019 / Revised: 24 April 2019 / Accepted: 25 April 2019 / Published: 29 April 2019
(This article belongs to the Special Issue Targeting Hedgehog Signaling in Cancer)
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Abstract

The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers. In this review article, we summarize pre-clinical evidence supporting the suitability of targeting this signaling pathway in cancers. We review agents blocking both the ligand-dependent and ligand-independent cascades, and discuss the clinical evidence, which has led to the FDA approval of Hedgehog receptor Smoothened inhibitors, vismodegib, and sonidegib, in different malignancies. Finally, we provide an overview of published and ongoing clinical trial data on single agent or combination therapeutic strategies, targeting Hedgehog/GLI signaling pathway, in both advanced solid tumors and hematologic malignancies. View Full-Text
Keywords: Hedgehog; Smoothened; GLI factors; clinical trials; vismodegib; sonidegib Hedgehog; Smoothened; GLI factors; clinical trials; vismodegib; sonidegib
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xie, H.; Paradise, B.D.; Ma, W.W.; Fernandez-Zapico, M.E. Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer. Cells 2019, 8, 394.

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