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Cells 2019, 8(3), 228; https://doi.org/10.3390/cells8030228

Cellular Proteostasis During Influenza A Virus Infection—Friend or Foe?

Institute of Biomedicine (iBiMED) and Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal
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Received: 16 February 2019 / Revised: 2 March 2019 / Accepted: 5 March 2019 / Published: 9 March 2019
(This article belongs to the Special Issue Host–Pathogen Interactions During Influenza Virus Infection)
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Abstract

In order to efficiently replicate, viruses require precise interactions with host components and often hijack the host cellular machinery for their own benefit. Several mechanisms involved in protein synthesis and processing are strongly affected and manipulated by viral infections. A better understanding of the interplay between viruses and their host-cell machinery will likely contribute to the development of novel antiviral strategies. Here, we discuss the current knowledge on the interactions between influenza A virus (IAV), the causative agent for most of the annual respiratory epidemics in humans, and the host cellular proteostasis machinery during infection. We focus on the manipulative capacity of this virus to usurp the cellular protein processing mechanisms and further review the protein quality control mechanisms in the cytosol and in the endoplasmic reticulum that are affected by this virus. View Full-Text
Keywords: influenza A virus (IAV); virus–host interaction; proteostasis; protein quality control; protein aggregation; unfolded protein response influenza A virus (IAV); virus–host interaction; proteostasis; protein quality control; protein aggregation; unfolded protein response
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Marques, M.; Ramos, B.; Soares, A.R.; Ribeiro, D. Cellular Proteostasis During Influenza A Virus Infection—Friend or Foe? Cells 2019, 8, 228.

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