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Cells
Volume 10
Issue 5
10.3390/cells10050972
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Article

Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression

by
Barbara Planchez
1,
Natalia Lagunas
1,
Anne-Marie Le Guisquet
1,
Marc Legrand
1,
Alexandre Surget
1,
René Hen
2,3,4 and
Catherine Belzung
1,*
1
UMR 1253, iBrain, Université de Tours, Inserm, CEDEX 1, 37032 Tours, France
2
Departments of Neuroscience, Psychiatry & Pharmacology, Columbia University, New York, NY 10027, USA
3
Division of Integrative Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
4
Kavli Institute for Brain Sciences, Columbia University, New York, NY 10027, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Boldizsár Czéh
Cells 2021, 10(5), 972; https://doi.org/10.3390/cells10050972
Received: 25 March 2021 / Revised: 13 April 2021 / Accepted: 19 April 2021 / Published: 21 April 2021
(This article belongs to the Special Issue Chronic Stress Models for Mood Disorders 2020)
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Abstract

Many studies evaluated the functional role of adult hippocampal neurogenesis (AHN) and its key role in cognitive functions and mood regulation. The effects of promoting AHN on the recovery of stress-induced symptoms have been well studied, but its involvement in stress resilience remains elusive. We used a mouse model enabling us to foster AHN before the exposure to unpredictable chronic mild stress (UCMS) to evaluate the potential protective effects of AHN on stress, assessing the depressive-like phenotype and executive functions. For this purpose, an inducible transgenic mouse model was used to delete the pro-apoptotic gene Bax from neural progenitors four weeks before UCMS, whereby increasing the survival of adult-generated neurons. Our results showed that UCMS elicited a depressive-like phenotype, highlighted by a deteriorated coat state, a higher immobility duration in the tail suspension test (TST), and a delayed reversal learning in a water maze procedure. Promoting AHN before UCMS was sufficient to prevent the development of stressed-induced behavioral changes in the TST and the water maze, reflecting an effect of AHN on stress resilience. Taken together, our data suggest that increasing AHN promotes stress resilience on some depressive-like symptoms but also in cognitive symptoms, which are often observed in MD. View Full-Text
Keywords: depression; adult hippocampal neurogenesis; chronic stress; inhibition; flexibility; depressive-like behaviors; hippocampus; stress resilience depression; adult hippocampal neurogenesis; chronic stress; inhibition; flexibility; depressive-like behaviors; hippocampus; stress resilience
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MDPI and ACS Style

Planchez, B.; Lagunas, N.; Le Guisquet, A.-M.; Legrand, M.; Surget, A.; Hen, R.; Belzung, C. Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression. Cells 2021, 10, 972. https://doi.org/10.3390/cells10050972

AMA Style

Planchez B, Lagunas N, Le Guisquet A-M, Legrand M, Surget A, Hen R, Belzung C. Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression. Cells. 2021; 10(5):972. https://doi.org/10.3390/cells10050972

Chicago/Turabian Style

Planchez, Barbara, Natalia Lagunas, Anne-Marie Le Guisquet, Marc Legrand, Alexandre Surget, René Hen, and Catherine Belzung. 2021. "Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression" Cells 10, no. 5: 972. https://doi.org/10.3390/cells10050972

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