Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Experimental Acute Pancreatitis
2.3. Histological Analysis and Biochemical Measurements of Acute Pancreatitis
2.4. Cell Preparation and Solutions
2.5. Immunofluorescence
2.6. Western Blotting
2.7. Measurement of Necrosis and Apoptosis
2.8. Measurement of Cytosolic Calcium and Reactive Oxygen Species
2.9. Statistical Analysis
3. Results
3.1. Effects of Genetic and Pharmacological RIPK1 Inhibition in FAEE-AP, TLCS-AP and CER-AP
3.2. Protective Effects of IDO Inhibition in TLCS-AP
3.3. Comparative Effects of RIPK1K45A and Nec-1 on PAC Cell Death
3.4. Comparative Effects of RIPK1K45A and Nec-1 on Intracellular Ca2+ and ROS
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Ouyang, Y.; Wen, L.; Armstrong, J.A.; Chvanov, M.; Latawiec, D.; Cai, W.; Awais, M.; Mukherjee, R.; Huang, W.; Gough, P.J.; et al. Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1. Cells 2021, 10, 1035. https://doi.org/10.3390/cells10051035
Ouyang Y, Wen L, Armstrong JA, Chvanov M, Latawiec D, Cai W, Awais M, Mukherjee R, Huang W, Gough PJ, et al. Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1. Cells. 2021; 10(5):1035. https://doi.org/10.3390/cells10051035
Chicago/Turabian StyleOuyang, Yulin, Li Wen, Jane A. Armstrong, Michael Chvanov, Diane Latawiec, Wenhao Cai, Mohammad Awais, Rajarshi Mukherjee, Wei Huang, Peter J. Gough, and et al. 2021. "Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1" Cells 10, no. 5: 1035. https://doi.org/10.3390/cells10051035
APA StyleOuyang, Y., Wen, L., Armstrong, J. A., Chvanov, M., Latawiec, D., Cai, W., Awais, M., Mukherjee, R., Huang, W., Gough, P. J., Bertin, J., Tepikin, A. V., Sutton, R., & Criddle, D. N. (2021). Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1. Cells, 10(5), 1035. https://doi.org/10.3390/cells10051035