Next Article in Journal
Supported Ionic Liquid Silica as Curing Agent for Epoxy Composites with Improved Mechanical and Thermal Properties
Next Article in Special Issue
Vesicles in Multiple Shapes: Fine-Tuning Polymersomes’ Shape and Stability by Setting Membrane Hydrophobicity
Previous Article in Journal
Synthesis of Polystyrene–Polyphenylsiloxane Janus Particles through Colloidal Assembly with Unexpected High Selectivity: Mechanistic Insights and Their Application in the Design of Polystyrene Particles with Multiple Polyphenylsiloxane Patches
Previous Article in Special Issue
Effects of Lateral and Terminal Chains of X-Shaped Bolapolyphiles with Oligo(phenylene ethynylene) Cores on Self-Assembly Behaviour. Part 1: Transition between Amphiphilic and Polyphilic Self-Assembly in the Bulk
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessFeature PaperArticle
Polymers 2017, 9(10), 476; https://doi.org/10.3390/polym9100476

Effects of Lateral and Terminal Chains of X-Shaped Bolapolyphiles with Oligo(phenylene ethynylene) Cores on Self-Assembly Behavior. Part 2: Domain Formation by Self-Assembly in Lipid Bilayer Membranes

1
Department of Chemistry, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle, Germany
2
Department of Chemistry, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 2, 06120 Halle, Germany
*
Author to whom correspondence should be addressed.
Received: 1 September 2017 / Revised: 20 September 2017 / Accepted: 22 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue From Amphiphilic to Polyphilic Polymers)
Full-Text   |   PDF [2910 KB, uploaded 29 September 2017]   |  

Abstract

Supramolecular self-assembly of membrane constituents within a phospholipid bilayer creates complex functional platforms in biological cells that operate in intracellular signaling, trafficking and membrane remodeling. Synthetic polyphilic compounds of macromolecular or small size can be incorporated into artificial phospholipid bilayers. Featuring three or four moieties of different philicities, they reach beyond ordinary amphiphilicity and open up avenues to new functions and interaction concepts. Here, we have incorporated a series of X-shaped bolapolyphiles into DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) bilayers of giant unilamellar vesicles. The bolapolyphiles consist of a rod-like oligo(phenylene ethynylene) (OPE) core, hydrophilic glycerol-based headgroups with or without oligo(ethylene oxide) expansions at both ends and two lateral alkyl chains attached near the center of the OPE core. In the absence of DPPC and water, the compounds showed thermotropic liquid-crystalline behavior with a transition between polyphilic and amphiphilic assembly (see part 1 in this issue). In DPPC membranes, various trends in the domain morphologies were observed upon structure variations, which entailed branched alkyl chains of various sizes, alkyl chain semiperfluorination and size expansion of the headgroups. Observed effects on domain morphology are interpreted in the context of the bulk behavior (part 1) and of a model that was previously developed based on spectroscopic and physicochemical data. View Full-Text
Keywords: self-organization; self-assembly; amphiphiles; polyphiles; bolaamphiphiles; confocal fluorescence microscopy; membrane organization; phase separation; giant unilamellar vesicles; umbrella model self-organization; self-assembly; amphiphiles; polyphiles; bolaamphiphiles; confocal fluorescence microscopy; membrane organization; phase separation; giant unilamellar vesicles; umbrella model
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Werner, S.; Ebenhan, J.; Poppe, M.; Poppe, S.; Ebert, H.; Tschierske, C.; Bacia, K. Effects of Lateral and Terminal Chains of X-Shaped Bolapolyphiles with Oligo(phenylene ethynylene) Cores on Self-Assembly Behavior. Part 2: Domain Formation by Self-Assembly in Lipid Bilayer Membranes. Polymers 2017, 9, 476.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top