Next Article in Journal
Study on Micro Production Mechanism of Corner Residual Oil after Polymer Flooding
Previous Article in Journal
Development of Intracorporeal Differentiation of Stem Cells to Induce One-Step Mastoid Bone Reconstruction during Otitis Media Surgeries
Review

Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review

1
The CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an 271016, China
2
Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dentistry, Korea University, Seoul 08308, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Young-Sam Cho
Polymers 2022, 14(5), 871; https://doi.org/10.3390/polym14050871
Received: 23 January 2022 / Revised: 13 February 2022 / Accepted: 14 February 2022 / Published: 23 February 2022
(This article belongs to the Section Polymer Applications)
Guided tissue/bone regeneration (GTR/GBR) is commonly applied in dentistry to aid in the regeneration of bone/tissue at a defective location, where the assistive material eventually degrades to be substituted with newly produced tissue. Membranes separate the rapidly propagating soft tissue from the slow-growing bone tissue for optimal tissue regeneration results. A broad membrane exposure area, biocompatibility, hardness, ductility, cell occlusion, membrane void ratio, tissue integration, and clinical manageability are essential functional properties of a GTR/GBR membrane, although no single modern membrane conforms to all of the necessary characteristics. This review considers ongoing bone/tissue regeneration engineering research and the GTR/GBR materials described in this review fulfill all of the basic ISO requirements for human use, as determined through risk analysis and rigorous testing. Novel modified materials are in the early stages of development and could be classified as synthetic polymer membranes, biological extraction synthetic polymer membranes, or metal membranes. Cell attachment, proliferation, and subsequent tissue development are influenced by the physical features of GTR/GBR membrane materials, including pore size, porosity, and mechanical strength. According to the latest advances, key attributes of nanofillers introduced into a polymer matrix include suitable surface area, better mechanical capacity, and stability, which enhances cell adhesion, proliferation, and differentiation. Therefore, it is essential to construct a bionic membrane that satisfies the requirements for the mechanical barrier, the degradation rate, osteogenesis, and clinical operability. View Full-Text
Keywords: guided tissue regeneration; guided bone regeneration; biodegradable polymer; membrane; material modification guided tissue regeneration; guided bone regeneration; biodegradable polymer; membrane; material modification
Show Figures

Figure 1

MDPI and ACS Style

Gao, Y.; Wang, S.; Shi, B.; Wang, Y.; Chen, Y.; Wang, X.; Lee, E.-S.; Jiang, H.-B. Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review. Polymers 2022, 14, 871. https://doi.org/10.3390/polym14050871

AMA Style

Gao Y, Wang S, Shi B, Wang Y, Chen Y, Wang X, Lee E-S, Jiang H-B. Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review. Polymers. 2022; 14(5):871. https://doi.org/10.3390/polym14050871

Chicago/Turabian Style

Gao, Yue, Shuai Wang, Biying Shi, Yuxuan Wang, Yimeng Chen, Xuanyi Wang, Eui-Seok Lee, and Heng-Bo Jiang. 2022. "Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review" Polymers 14, no. 5: 871. https://doi.org/10.3390/polym14050871

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop