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Open AccessArticle

Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials

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Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
2
National Research Center for Micro and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
3
Department of Chemical Thermodynamics, “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 060021 Bucharest, Romania
4
Department of Biochemistry, Faculty of Veterinary Medicine, University of Agronomic Science and Veterinary Medicine, 011464 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(5), 1161; https://doi.org/10.3390/polym12051161
Received: 30 April 2020 / Revised: 8 May 2020 / Accepted: 12 May 2020 / Published: 19 May 2020
This paper proposes the development of a biomimetic composite based on naturally derived biomaterials. This freeze-dried scaffold contains a microwave-synthesized form of biomimetic hydroxyapatite (HAp), using the interwoven hierarchical structure of eggshell membrane (ESM) as bio-template. The bone regeneration capacity of the scaffold is enhanced with the help of added tricalcium phosphate from bovine Bone ash (BA). With the addition of Gelatin (Gel) and Chitosan (CS) as organic matrix, the obtained composite is characterized by the ability to stimulate the cellular response and might accelerate the bone healing process. Structural characterization of the synthesized HAp (ESM) confirms the presence of both hydroxyapatite and monetite phases, in accordance with the spectroscopy results on the ESM before and after the microwave thermal treatment (the presence of phosphate group). Morphology studies on all individual components and final scaffold, highlight their morphology and porous structure, characteristics that influence the biocompatibility of the scaffold. Porosity, swelling rate and the in vitro cytotoxicity assays performed on amniotic fluid stem cells (AFSC), demonstrate the effective biocompatibility of the obtained materials. The experimental results presented in this paper highlight an original biocomposite scaffold obtained from naturally derived materials, in a nontoxic manner. View Full-Text
Keywords: biocomposite; scaffold; eggshell membrane; chitosan; gelatin; hydroxyapatite; bone ash biocomposite; scaffold; eggshell membrane; chitosan; gelatin; hydroxyapatite; bone ash
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MDPI and ACS Style

Neacsu, I.A.; Serban, A.P.; Nicoara, A.I.; Trusca, R.; Ene, V.L.; Iordache, F. Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials. Polymers 2020, 12, 1161.

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