Next Article in Journal
Evolution of Interfacial Friction Angle and Contact Area of Polymer Pellets during the Initial Stage of Ultrasonic Plasticization
Previous Article in Journal
Development of Multi-Functional Graphene Polymer Composites Having Electromagnetic Interference Shielding and De-Icing Properties
Open AccessArticle

Thiol–Ene Click Reaction Initiated Rapid Gelation of PEGDA/Silk Fibroin Hydrogels

State Key Laboratory of Silkworm Genome Biology, College of Biotechnology, Southwest University, Chongqing 400715, China
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(12), 2102; https://doi.org/10.3390/polym11122102
Received: 7 October 2019 / Revised: 28 November 2019 / Accepted: 12 December 2019 / Published: 14 December 2019
(This article belongs to the Section Biomacromolecules, Biobased and Biodegradable Polymers)
In this work, poly(ethylene glycol) diacrylate (PEGDA) molecules were grafted to silk fibroin (SF) molecules via a thiol–ene click reaction under 405 nm UV illumination for the fabrication of a PEGDA/SF composite hydrogel. The composite hydrogels could be prepared in a short and controllable gelation time without the use of a photoinitiator. Features relevant to the drug delivery of the PEGDA/SF hydrogels were assessed, and the hydrogels were characterized by various techniques. The results showed that the prepared PEGDA/SF hydrogels demonstrated a good sustained-release performance with limited swelling behavior. It was found that a prior cooling step can improve the compressive strength of the hydrogels effectively. Additionally, the MTT assay indicated the prepared PEGDA/SF hydrogel is non-cytotoxic. Subcutaneous implantation of the PEGDA/SF hydrogel in Kunming mice did not induce an obvious inflammation, which revealed that the prepared PEGDA/SF hydrogel possessed good biocompatibility. Furthermore, the mechanism of the gelation process was discussed. View Full-Text
Keywords: silk fibroin; PEGDA; thiol–ene click reaction; gelation; drug delivery silk fibroin; PEGDA; thiol–ene click reaction; gelation; drug delivery
Show Figures

Graphical abstract

MDPI and ACS Style

Liang, J.; Zhang, X.; Chen, Z.; Li, S.; Yan, C. Thiol–Ene Click Reaction Initiated Rapid Gelation of PEGDA/Silk Fibroin Hydrogels. Polymers 2019, 11, 2102. https://doi.org/10.3390/polym11122102

AMA Style

Liang J, Zhang X, Chen Z, Li S, Yan C. Thiol–Ene Click Reaction Initiated Rapid Gelation of PEGDA/Silk Fibroin Hydrogels. Polymers. 2019; 11(12):2102. https://doi.org/10.3390/polym11122102

Chicago/Turabian Style

Liang, Jianwei; Zhang, Xiaoning; Chen, Zhenyu; Li, Shan; Yan, Chi. 2019. "Thiol–Ene Click Reaction Initiated Rapid Gelation of PEGDA/Silk Fibroin Hydrogels" Polymers 11, no. 12: 2102. https://doi.org/10.3390/polym11122102

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop