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Polymers 2018, 10(9), 991; https://doi.org/10.3390/polym10090991

Synthesis and in Vitro Cytocompatibility of Segmented Poly(Ester-Urethane)s and Poly(Ester-Urea-Urethane)s for Bone Tissue Engineering

1
Departamento de Ingeniería Metalúrgica, Instituto Politécnico Nacional, ESIQIE, UPALM-Zacatenco, Col Lindavista, México City 07738, Mexico
2
Instituto de ciencia y tecnología de Polímeros, ICTP-CSIC calle Juan de la Cierva 3, 28006 Madrid, Spain
3
CIBER-BBN, C. Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 31 July 2018 / Revised: 31 August 2018 / Accepted: 1 September 2018 / Published: 5 September 2018
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Abstract

Two series of segmented polyurethanes were obtained and their mechanical and thermal properties as well as their biodegradability and cytotoxicity were evaluated. The chemical nature of the polyurethanes was varied by using either 1,4 butanediol (poly-ester-urethanes, PEUs) or l-lysine ethyl ester dihydrochloride (poly-ester-urea-urethanes, PEUUs) as chain extenders. Results showed that varying the hard segment influenced the thermal and mechanical properties of the obtained polymers. PEUs showed strain and hardness values of about 10–20 MPa and 10–65 MPa, respectively. These values were higher than the obtained values for the PEUUs due to the phase segregation and the higher crystallinity observed for the polyester-urethanes (PEUs); phase segregation was also observed and analyzed by XRD and DSC. Moreover, both series of polymers showed hydrolytic degradation when they were submerged in PBS until 90 days with 20% of weight loss. In vitro tests using a Human Osteoblastic cell line (Hob) showed an average of 80% of cell viability and good adhesion for both series of polymers. View Full-Text
Keywords: polyurethanes; biodegradable polymers; cytocompatibility; human osteoblastic cells polyurethanes; biodegradable polymers; cytocompatibility; human osteoblastic cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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González-García, D.M.; Marcos-Fernández, Á.; Rodríguez-Lorenzo, L.M.; Jiménez-Gallegos, R.; Vargas-Becerril, N.; Téllez-Jurado, L. Synthesis and in Vitro Cytocompatibility of Segmented Poly(Ester-Urethane)s and Poly(Ester-Urea-Urethane)s for Bone Tissue Engineering. Polymers 2018, 10, 991.

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