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Polymers 2018, 10(12), 1323; https://doi.org/10.3390/polym10121323

Novel Bacterial Cellulose-Poly (Acrylic Acid) Hybrid Hydrogels with Controllable Antimicrobial Ability as Dressings for Chronic Wounds

1
Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, South Australia 5042, Australia
2
Key Laboratory of Advanced Textile Composite Materials of Ministry of Education, Institute of Textile Composite, School of Textile, Tianjin Polytechnic University, Tianjin 300387, China
3
Medical Device Research Institute, College of Science and Engineering, Flinders University, South Australia 5042, Australia
*
Author to whom correspondence should be addressed.
Received: 12 October 2018 / Revised: 21 November 2018 / Accepted: 27 November 2018 / Published: 29 November 2018
(This article belongs to the Special Issue Nanotechnology of Polymers and Biomaterials)
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Abstract

This investigation examines the combination of poly (acrylic acid) (PAA) and bacterial cellulose (BC) nanofibers to synthesize hydrogel hybrid composites used for wound dressing application. Amoxicillin (AM) was also grafted onto the composites for drug release. Fourier transform infrared analysis and scanning electron microscopy conducted revealed the structure and porosity of the composite being developed, as well as the successful fabrication of BC-PAA composites. The results of mechanical testing and hygroscopicity revealed that the composite shows higher stability than hydrogels which are currently used worldwide, albeit with a slight reduction in swelling capabilities. However, the composite was revealed to be responsive to a rise in pH values with an increase in composite swelling and drug release. These results together with their morphological characteristics suggest that BC-PAA hydrogel hybrid composite is a promising candidate for wound dressing application. View Full-Text
Keywords: poly (acrylic acid), bacterial cellulose; hydrogel; wound dressing; antimicrobial poly (acrylic acid), bacterial cellulose; hydrogel; wound dressing; antimicrobial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chuah, C.; Wang, J.; Tavakoli, J.; Tang, Y. Novel Bacterial Cellulose-Poly (Acrylic Acid) Hybrid Hydrogels with Controllable Antimicrobial Ability as Dressings for Chronic Wounds. Polymers 2018, 10, 1323.

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