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Extending the pool of compatible peptide hydrogels for protein crystallization

Laboratorio de Estudios Cristalográficos, Instituto Andaluz de Ciencias de la Tierra (Consejo Superior de Investigaciones Científicas-Universidad de Granada), Avenida de las Palmeras 4, 18100 Armilla, Granada, Spain
Departamento de Química Orgánica, Universidad de Granada, C. U. Fuentenueva, Avda. Severo Ochoa s/n, E-18071 Granada, Spain
ALBA Synchrotron, Carrer de la Llum 2-26, Cerdanyola del Vallès, 08290 Barcelona, Spain
Departamento de Física Aplicada, Facultad de Ciencias, (UGR), Spain
Authors to whom correspondence should be addressed.
Crystals 2019, 9(5), 244;
Received: 5 April 2019 / Revised: 3 May 2019 / Accepted: 7 May 2019 / Published: 10 May 2019
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Short-peptide supramolecular (SPS) hydrogels are a class of materials that have been found to be useful for (bio)technological applications thanks to their biocompatible nature. Among the advantages reported for these peptides, their economic affordability and easy functionalization or modulation have turned them into excellent candidates for the development of functional biomaterials. We have recently demonstrated that SPS hydrogels can be used to produce high-quality protein crystals, improve their properties, or incorporate relevant materials within the crystals. In this work, we prove that hydrogels based on methionine and tyrosine are also good candidates for growing high-quality crystals of the three model proteins: lysozyme, glucose isomerase, and thaumatin. View Full-Text
Keywords: protein crystallization; composite crystals; peptide hydrogels protein crystallization; composite crystals; peptide hydrogels

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Escolano-Casado, G.; Contreras-Montoya, R.; Conejero-Muriel, M.; Castellví, A.; Juanhuix, J.; Lopez-Lopez, M.T.; Álvarez de Cienfuegos, L.; Gavira, J.A. Extending the pool of compatible peptide hydrogels for protein crystallization. Crystals 2019, 9, 244.

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