Abstract
There are two common categories of implants that are used in medical sciences, i.e., orthopedic and dental ones. In this study, dental implant materials are focused such as Ti6Al4V alloys that are used for the replacement of lost teeth due to their high strength and biocompatibility. However, they cause infections in nearby tissues due to elemental release (potentially Al and V). Thus, manganese is selected to be incorporated into the alloy since it is also present in the human body in the form of traces. Different sets of implants were produced, i.e., Ti5Mn and Ti10Mn (where 5 and 10 describe the percentage of Mn) by using the powder metallurgy technique. This was followed by characterization techniques, including X-ray fluorescence spectroscopy (XRF), X-ray diffractometer (XRD), optical microscope (OM), and nanoindenter. The very aim of this study is to compare the microstructural evolutions, density, and mechanical properties of reference alloys and the ones produced in this study. Results show the microstructure of Ti6Al4V consists of the alpha (α) and beta (β) phases, while Ti5Mn and Ti10Mn revealed the beta (β) phases. The Ti5Mn alloy showed excellent mechanical properties than that of the Ti6Al4V counterpart. Extensive discussion is presented in light of the observed results. The relative density of Ti5Mn alloy was found to be enhanced than that of reference alloy.
1. Introduction
Titanium (Ti) and the alloys based on it are a superb choice for implant applications, owing to their mechanical characteristics, as well as those deliberated by the surface, i.e., resistance to corrosion and bioactivity []. The vital features of Ti-alloys which make them ideal alternate for biomedical applications include their light weight, good mechanical strength, high resistance to corrosion, excellent biocompatibility, nonmagnetic characteristics, and comparatively low modulus of elasticity [,]. However, Ti6Al4V alloy is made out of cytotoxic elements, such as aluminum (Al) and vanadium (V), that may cause extreme issues once delivered to the human body. The reason behind the cytotoxicity of aluminum and vanadium is that the living body is an aggressive environment composed of water, saliva, complex organic compounds, plasma, lymph, and different types of ions that electrochemically react with the implant and cause corrosion. Previous research shows that vanadium ions release from alloys within the human body via a passive dissolution mechanism that causes discoloration of the neighboring tissue or produces an inflammatory reaction that is the reason of discomfort and may cause loosening of the implant due to osteolysis [].
Moreover, Al reveals only a single oxidation state, i.e., Al3+, which has negative chemical affinity, and it behaves like an oxygen-donor ligand. Various complex compounds that contain carboxylate, inorganic, deprotonated hydroxyl, and organic phosphates groups form strong chemical bonds with Al3+. Due to this chemical behavior, Al3+ forms bonds to the phosphate groups of DNA and RNA, disturbing the DNA chemical structure and manipulating the appearance of several genes crucial for brain roles [].
To beat the possible aluminum and vanadium toxic effect, it was replaced by manganese (Mn), prompting the formation of a new V-free titanium-based alloy []. As a stable component, Mn influenced the β phase with a strong solid solution strengthening effect. Mn, as a trace element, assumes a significant part in maintaining normal metabolism []. Manganese was selected due to minimal cost, capacity to enhance the mechanical characteristics of titanium through the development of two-stage microstructures, and connection with the living body. Mn supports [] bone growth and stimulates several vital enzyme systems and due to this ability, it is a requisite for the synthesis of acid mucopolysaccharides, such as chondroitin sulfate, to produce the matrices of bones. Moreover, manganese plays the role of a co-factor in the production of bone cartilage and collagen, as well as in bone mineralization []. Thus, in comparison to other β stabilizers, the Mn, which is naturally available in large quantities, has a lower toxic effect and lower cost [,].
Consequently, it is significant to compare the mechanical properties of Ti6Al4V, Ti5Mn, and Ti10Mn alloys. While ordinary testing strategies are generally utilized for estimating the mechanical properties of bulk materials, for ordinary specimen geometries, such as small sample sizes or rough shapes, which are difficult to test, nanoindentation is a grounded strategy for estimating the mechanical characteristics of a varied scope of materials particularly when a nondestructive methodology is mandatory [].
Lately, the nanoindentation strategy has been introduced as an option in contrast to the regular testing strategies, since it is straightforward, quick, nondestructive, generally cheap, and requires a small size of the specimen [,,,].
Nanoindentation has been a progressively current technique for material characterization on a nanoscale [] due to its high spatial and depth resolution of the measurement []. Several mechanical properties of a coating/substrate system may be acquired using the nanoindentation technique. Due to its high hardness and elastic modulus diamond is often used as a tip of the indenter [].
A characteristic measurement that a nanoindenter can record is the displacement (h) from the material surface in sub-nm and load (P) in sub-mN. From the documented P vs. h curve, several characteristics of the material, such as the yield strength, elastic modulus, residual stress, hardness, fracture toughness, and strain hardening exponent, can be directly calculated [,].
Numerous methods are available in the fabrication of Ti-based alloys for different biomedical applications, such as selective laser melting, metal injection molding, electron beam melting, powder metallurgy, etc., owing to their high melting point, contamination susceptibility, and reactivity at high temperature, the Ti alloys are problematic to be formed from casting [,]. A foremost hindrance to the usage of titanium-based alloys in numerous probable biomedical uses is that they are expensive, mostly for the accompanying cost of machining, as well as the expense to refine Ti sponges. The usage of the powder metallurgy method is a promising alternative, as it ensures not merely the manufacturing of net-shape components, but similarly, considerably cuts production expenses. It was stated that the usage of powder metallurgy permits achieving a <20% decrease of unused material. Additionally, in 2009 Zhang et al. [] studied powder metallurgy, the Ti-Mn alloys containing 8 and 12% Mn were designed by spark plasma sintering verified that it promoted the cell adhesion properties. The authors finalized that adding Mn in the Ti matrix might be a reason for the major rise in the Young modulus and hardness of the titanium-based alloys, although at a similar time decreasing the α to β transformation temperature. This method offers an additional benefit in that a tougher linking of the implant surface with the nearby tissues can be attained by bone growth onto the porous titanium surface, resulting in enhanced fatigue strength and wholly upgraded biocompatible properties. Because of these reasons, powder metallurgy is a promising route for the production of Ti alloys, as it produces net-shape components [].
In this research, Ti6Al4V, Ti5Mn, and Ti10Mn alloys are produced by the powder metallurgy method. The main objective of this research is to design a new material for biomedical applications that must not be cytotoxic. To achieve this objective, manganese is selected as an alloying element with titanium as it is low-cost material and its cytotoxicity level is low as compared to aluminum and vanadium. After the production of existing and new alloys via the powder metallurgy method, they were characterized by the nanoindentation method to compare the mechanical properties, such as hardness, elastic modulus, wear resistance of Ti6Al4V, Ti5Mn, and Ti10Mn alloys, in addition to microstructures.
2. Materials and Methods
2.1. Materials
The materials chosen to do the fabrication of Ti-based alloys for biomedical applications are pure titanium (Ti), aluminum (Al), vanadium (V), and manganese (Mn) powders. Titanium is nominated as a matrix material and manganese is used as an alloying agent.
2.2. Methods
Ti6Al4V, Ti5Mn, and Ti10Mn alloys were produced by the powder metallurgy method. The reason behind the selection of manganese concentration is that the Mn < 13 wt% can be utilized to yield noble biocompatible alloys [] The first one has 6wt% aluminum and 4 wt% vanadium, the second one has 5 wt% Mn, while the third has 5wt% Mn. Afterward, for all sets of samples, the powders were weighted in an inert atmosphere by using a glove box (TOB-STX2). Each component of the calculated composition was mechanically alloyed for 1 h at 300 rpm to get the homogenized powder via ball milling equipment 4 Tank Mixer (Desktop Vertical Automatic Mixer model, MTI Corporation (Richmond, CA, USA). Steel balls were selected as grinding media having the ball-to-powder ratio = 15:1. The powders were then compacted by using a die compaction setup with 8000 psi being pressure applied for 300 s. The sintering was performed at 900 °C with a heating rate of 5 °C/min in a vacuum furnace for 3 h. The main aim of the sintering step was to bind the powder particles together and finally produce the sintered alloys.
2.3. X-ray Fluorescence
X-ray fluorescence (XRF, ZSX primus, Rigaku, Japan) was used to identify the compositional change in the titanium alloy coupons’ surface.
2.4. Phase Composition Examination
PANanalytcial X-pert Pro XRD DY3313 (Eindhoven, the Netherlands) was used for the investigation of the phases present in the developed alloys. The diffracted peaks were noted in the range of 10–80°over 2θ at a speed of 0.1°/s.
2.5. Microstructural Analysis
Sintered samples with finalized dimensions (diameter = 30 mm and height = 6 mm) were manufactured. For microstructural characterization, the samples underwent several steps: (1) the surface was first ground via silicon carbide (SiC) paper (220 to 1200 grade). (2) Samples were then polished followed by washing with acetone and swapping with distilled water. They were then dried out with purified air. (3) Next, the etching of the samples was done via Kroll’s reagent to expose its micrograph []. (4) The microstructural evaluation of the samples was examined via OM. All experimentations were performed at room temperature.
2.6. Relative Density and Porosity
The relative density of all titanium-based alloys was determined via Equation (1) and porosity was calculated using Equation (2), where , and represent the relative, sintered, and green compact density of alloys, respectively, and Pt represents the total porosity of alloys:
2.7. Nanoindentation
In this research, nanoindentation tests were executed on an Anton Paar nanoindenter (UHT3). A Berkovich indenter (armed with a three-sided pyramid) made of diamond is used to perform the nanoindentation tests. The ultimate goal of this technique is to calculate the penetration depth of an indenter tip against the load applied to a well-polished mirror-like superficial surface of the sample. All the indentation tests were in good agreement with ISO 14577. Preceding the measurement, calibration of the tip was completed on fused silica to conserve accurateness. During the tests, the parameters were as follows: dwell time = 30 sec, loading rate = 1 mN/s, indenter geometry shape factor = 1.0, and maximum load = 50 mN []. The hardness, H is calculated by using Equation (3) []:
2.7.1. Elastic Modulus
Er, i.e., the reduced elastic modulus, is the sum of the elastic modulus of both the alloys and the indenter tip. This was calculated as per work done by Zhang et al. [].
2.7.2. Yield Pressure and Wear Properties
Yield pressure is the capability of the material to resist plastic deformation after the application of load, and this can be determined by using the ratio of hardness and reduced elastic modulus given in Equation (4):
At the same time, wear properties of alloys are directly related to the ratio of hardness and elastic moduli and calculated yield pressure values.
3. Results
3.1. Elemental Analysis
The chemical compositions of titanium, aluminum, manganese, and vanadium powders were determined by using X-ray Fluorescence (XRF). X-ray fluorescence (XRF) is used to analyze the purity of powders that are used in as-received conditions, shown in Table 1.

Table 1.
The purity level of different powders by using XRF analysis.
3.2. Microstructural Characterization
The microstructure of titanium-based alloys is typically observed in terms of the size, arrangement, and shape of α and β phases, as represented in Figure 1a–c. in case of Ti-5Mn, equiaxed and elongated grains are perceived, while in the case of Ti-10Mn alloys, equiaxed grains are observed in microstructures.

Figure 1.
(a,b) show the (α) alpha and (β) beta phases of Ti-5Mn and Ti-10Mn alloys (400×), respectively, and (c) shows the optical structure of Ti6Al4V alloy (400×).
3.3. Phase Composition Examination
XRD pattern of the titanium-based alloys is presented in Figure 2. The pattern confirms the presence of alpha and beta phases in the Ti5Mn and Ti6Al4V alloys and a beta phase in the Ti10Mn alloy. This result is also in compliance with the work done by Azmat et al. [].

Figure 2.
The XRD pattern of the titanium-based alloys. The pink line represents Ti5Mn, the brown line represents Ti10Mn, and the blue line represents Ti6Al4V.
3.4. Relative Density
Figure 3 presents the relative densities and porosity level of the titanium-based alloys, which were calculated by using Equations (1) and (2). The direct relation of relative densities with the manganese content was observed, which results in a decrease in porosity level, i.e., the densification is maximum.

Figure 3.
The relative density and porosity of the titanium-based alloys.
3.5. Nanoindentation
3.5.1. Load versus displacement curves of the Ti6Al4V, Ti-10Mn, and Ti-5Mn alloy
Generally, nanoindentation tests consist of three stages:
- Loading stage;
- Holding stage;
- Unloading stage.
The loading curve further comprises two states: the elastic loading region, which indicates the elastic deformation, and then the plastic loading region, which indicates that the plastic deformation is observed. The second stage is ordinarily used to reveal the deformation process (time-dependent) of indented materials. In the third stage, the elastic recovery process is observed and the Oliver and Pharr (O–P) technique is used to calculate the E and H values []. Loading and unloading graphs are shown in Figure 4.

Figure 4.
The different stages of the load-displacement curve of Ti-5Mn, Ti10Mn, and Ti6Al4V. The blue line represents Ti10Mn, the red line represents Ti5Mn, and the black line represents Ti6Al4V.
3.5.2. Nanohardness
Nanoindentation testing is used to determine the hardness value at the maximum load in the load versus displacement curve. The nanohardness values were determined by using Equation (3) and the values of the existing alloy were associated with the new design alloy are shown in Figure 5. The figure shows the comparison of β-phase hardnesses, as it is considered to be important for biomedical applications. Hardness is defined as how resistant a material is when force is applied. Replacement of aluminum and vanadium by manganese revealed an increment in hardness value from 2264.1 MPa to 9109.2 MPa. As there are high chances that indentation at nano-level may have induced work hardening, hence a Vicker hardness test was also performed to compare the hardness of α and β phases with the bulk sample, and the result is shown in Table 2.

Figure 5.
The nanohardness of the titanium-based alloys.

Table 2.
The hardness values of α and β phases and the bulk sample.
3.5.3. Reduced Elastic Modulus of the Ti6Al4V, Ti-5Mn Alloy, and Ti-10Mn
Figure 6 shows comparatively Ti-5Mn has a high value of elastic modulus. Moreover, the calculated ratio of hardness (H) and reduced elastic modulus (Er) values of Ti6Al4V and Ti5Mn helps find the elastic behavior limit and also has an effect on the wear behavior of the alloy.

Figure 6.
The reduced elastic modulus of the titanium-based alloys.
3.5.4. Yield Pressure and Wear Properties
Figure 7 shows the comparative values of H/Er and H3/Er2 ratios for all alloys, calculated by using Equation (4). Ti-5Mn has a high value of yield pressure (resistance to plastic deformation in the presence of load) and an H/Er ratio. The enhancement in hardness (HIT) and reduced elastic modulus (Er2) value of Ti-5Mn shows enhanced wear resistance and resistance to plastic deformation.

Figure 7.
The yield pressure and wear properties of the titanium-based alloys.
4. Discussions
4.1. Elemental Analysis
The results show that powder is of high purity and this powder purity is directly related to the mechanical and biomedical properties of the finished alloys.
4.2. Microstructure
The optical micrograph of the sintered Ti6Al4V revealed the dual phases containing alternating layers of α and β phases, as illustrated in Figure 1c. The lamellar microstructure is linked with strength because of the α phase size that affects inferior ductility, which is also verified by Nalla and co-workers [].
The optical image of Ti-5Mn alloy is characterized as equiaxed and elongated grains and shown in Figure 1a. The amount of β lamella grows in quantity, and the interlamellar spacing declines as the Mn content rises from 5 to 10%. Ti10Mn consists of equiaxed β phase grains (Figure 1b), while thin extended grains are observed at the grain boundaries and inside the few grains. Certainly, no clusters of powders were observed, and therefore, the homogeneous microstructures are achieved, which was not related to the addition of the manganese powder percentage. The quantity of β lamella is dependent on the Mn content; it increases in number as well as abundance, but at the same time, the interlamellar spacing reduces with the increase in Mn amount. Regarding the micro constituents, the Ti5Mn and Ti10Mn microstructures are composed of equiaxed and extended grains [].
Generally, after the addition of Mn powder, the β phase stabilizes and its quantity uniformly rises []. Ti5Mn has the characteristic lamellar structure of both α and β phases due to the large quantity of β stabilizer, i.e., Mn incorporated into the Ti matrix.
4.3. Phase Composition Analysis
Referring to the XRD patterns in Figure 2, the Ti5Mn and Ti6Al4V alloys contained both alpha and beta phases, whereas only the beta phase is observed in the case of Ti10Mn alloy, which confirms that the beta phase of the alloy increases with the increase in manganese content. This is because manganese stabilizes the β-phase [,].
In Ti5Mn, the amount of beta lamella is influenced by the amount of Mn; as the Mn content rises, it becomes more numerous and rich, but at the same time, the interlamellar phase shrinks []. In comparison to Ti6Al4V, Ti5Mn contains a higher amount of a β stabilizer, which gives it the typical lamellar structure of both α and β phases [,].
4.4. Relative Density
The deviation of the relative density of the sintered binary TiMn alloys and Ti6Al4V alloys is shown in Figure 3. In total, 91% of relative density was observed by using a vacuum furnace during the sintering process, which shows that the density of alloys is directly related to the content of manganese. The homogeneity was confirmed via EDS examination, which specified the chemical composition in wt% of alloys, i.e., 99.07Ti-0.93Mn, 94.98Ti-5.02Mn, and 90.54Ti-9.46Mn. Ti5Mn alloys are categorized by a α + β lamellar microstructure (Figure 3) [].
4.5. Nanoindentation
Figure 4 reveals the load (P) versus displacement (h) curve of Ti5Mn, Ti10Mn, and Ti6Al4V, respectively, obtained during the nanoindentation tests. For all the specimens, the P versus h curve was observed to be smooth, but in the case of Ti5Mn, there was a considerable decrease in depth. The decrease specifies an increment in the hardness value of the newly designed alloy. Generally, the load-displacement curve depends on several factors, such as the force applied, the material onto which testing will be done, and environmental conditions during nanoindentation testing. Overall different materials possess different shapes of load versus displacement curves, and in this research, the curve profile shows that the material performs in both elastic and plastic mode. The reason behind the shifting of curves towards the left indicates that among all alloys, Ti5Mn efficiently reduced the displacement from 1200 to 600 (in the case of Ti6Al4V) because of the strengthening mechanism and load sharing capability. The Ti5Mn curve shows the least displacement, although Ti6Al4V indicates the uppermost maximum displacement and the maximum elastic modulus of 130.13 GPa. The gradient of unloading and modulus are strictly connected to the stiffness, which results in an increase in the modulus of elasticity. The loading part of the P versus h curve joins the complex reaction of the material to strain including elastic, although the unloading part of the curve for maximum materials contains mostly elastic recovery [,].
4.6. Nanohardness
The outcomes of the hardness testing show that the hardness of sintered samples is inversely related to the addition of Mn content, as it was observed that the hardness decreases from 180.0 to 336.7 MPa with the increase in Mn content. This is due to the formation of the ω phase in Ti-5Mn alloy and the effect of solid solution strengthening decreases with the increase in Mn content (Figure 5).
4.7. Er of the Ti6Al4V, Ti-5Mn Alloy, and Ti-10Mn
Solid solution hardening has an impact on both the hardness and elastic modulus properties of Ti(5–10)Mn, which is due to the presence of Mn and the quantity of the ω phase, a thermal in the alloys. Contrarily, the volume section of the omega (ω) phase decreases with an increase in Mn content, which results in a reduction in both nanohardness and Young’s modulus properties [], as shown in Figure 6.
4.8. Yield Pressure and Wear Properties
Enhanced wear properties (Figure 7) and yield pressure are significant features for biomedical applications, since dental implants are typically exposed to wear with the surrounding bone. Therefore, superior wear resistance can diminish the creation of wear debris that causes nontoxic reactions, resulting in implant loosening and the required modification in surgery. Ti-5Mn has high hardness as well as high wear properties. This is because the addition a minimum amount of Mn in a Ti-based alloys results in enhanced wear properties of the newly developed alloys [].
5. Conclusions
In the current research, manganese was selected as a β stabilizer to produce novel Ti-based alloys for biomedical usages, such as dental implants orthopedic applications, etc., at minimal expense. Cost declination depends not only on the selection of the alloying elements but also on the selection of the manufacturing route. Especially, this research validates that Ti-based alloys can fruitfully be produced via the powder metallurgy route. Based on the present set of experimental conditions, we provide some concluding remarks. Manganese addition has a profound effect on the hardness, elastic modulus, and microstructure of the alloy. Comparatively, the Ti5Mn alloy exhibits enhanced hardness and elastic modulus. However, a Ti5Mn alloy with 5 wt% Mn is suggested to be the best replacement for aluminum and vanadium for cell implantology because of high hardness and lower elastic modulus and wear properties. To conclude, the nanoindentation load can be properly adjusted to determine the mechanical properties as compared to conventional mechanical tests. It was also observed that nanoindentation can be used to measure the wear properties of the PM-fabricated Ti6Al4V, Ti5Mn, and Ti10Mn alloys.
Author Contributions
Conceptualization, A.D.C.; methodology, A.A. (Ambreen Azmat). and S.A.; writing, I.A.C., F.S. and J.A.; validation, I.A.C. and A.D.C.; investigation, J.A., I.A.C., S.A. and S.F.; supervision, A.D.C.; funding acquisition, M.A.S. and A.A. (Abdulaziz AlHazaa). All authors have read and agreed to the published version of the manuscript.
Funding
This research was funded by the Researcher’s Supporting Project Number (RSP-2021/269), King Saud University, Riyadh, Saudi Arabia.
Institutional Review Board Statement
Not applicable.
Informed Consent Statement
Not applicable.
Data Availability Statement
Data are available upon request from the corresponding authors.
Acknowledgments
The authors would like to acknowledge the Researcher’s Supporting Project Number (RSP-2021/269), King Saud University, Riyadh, Saudi Arabia, for their support of this work.
Conflicts of Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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