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Open AccessArticle

Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study

1
Physical and Biophysical Chemistry, Bielefeld University, 33615 Bielefeld, Germany
2
Soft Matter at Interfaces, Technical University of Darmstadt, 64289 Darmstadt, Germany
3
ESRF—The European Synchrotron, 38043 Grenoble CEDEX 9, France
4
Institut Laue-Langevin, DS/LSS, 38042 Grenoble CEDEX 9, France
*
Author to whom correspondence should be addressed.
Crystals 2020, 10(5), 401; https://doi.org/10.3390/cryst10050401
Received: 10 April 2020 / Revised: 8 May 2020 / Accepted: 11 May 2020 / Published: 16 May 2020
β -aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β -aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β -aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures. View Full-Text
Keywords: saponin; β-aescin; β-escin; lipid membrane; bicelle; nanodisk; wide-angle X-ray scattering; biosurfactant; ibuprofen saponin; β-aescin; β-escin; lipid membrane; bicelle; nanodisk; wide-angle X-ray scattering; biosurfactant; ibuprofen
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Geisler, R.; Prévost, S.; Dattani, R.; Hellweg, T. Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. Crystals 2020, 10, 401.

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