Catalysts 2016, 6(7), 106; https://doi.org/10.3390/catal6070106
Solvent-Free Selective Condensations Based on the Formation of the Olefinic (C=C) Bond Catalyzed by Organocatalyst
1
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
2
Graduate school, University of Chinese Academy of Sciences, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Aurelio G. Csákÿ and Keith Hohn
Received: 6 June 2016 / Revised: 4 July 2016 / Accepted: 14 July 2016 / Published: 20 July 2016
(This article belongs to the Special Issue Metal-free Organocatalysis)
Abstract
Pyrrolidine and its derivatives were used to catalyze aldol and Knoevenagel condensations for the formation of the olefinic (C=C) bond under solvent-free conditions. The 3-pyrrolidinamine showed high activity and afforded excellent yields of α,β-unsaturated compounds. The aldol condensation of aromatic/heterocyclic aldehydes with ketones affords enones in high conversion (99.5%) and selectivity (92.7%). Good to excellent yields of α,β-unsaturated compounds were obtained in the Knoevenagel condensation of aldehydes with methylene-activated substrates. View Full-TextKeywords:
aldol condensation; Knoevenagel condensation; organocatalysis; solvent-free condition; ketone; aldehyde
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Song, H.; Jin, R.; Jin, F.; Kang, M.; Li, Z.; Chen, J. Solvent-Free Selective Condensations Based on the Formation of the Olefinic (C=C) Bond Catalyzed by Organocatalyst. Catalysts 2016, 6, 106.
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