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Article

Not a Mistake but a Feature: Promiscuous Activity of Enzymes Meeting Mycotoxins

Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, Russia
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Author to whom correspondence should be addressed.
Academic Editors: Jing Zhao and Guochao Xu
Catalysts 2022, 12(10), 1095; https://doi.org/10.3390/catal12101095
Received: 23 August 2022 / Revised: 13 September 2022 / Accepted: 19 September 2022 / Published: 22 September 2022
(This article belongs to the Special Issue Advances in Biocatalysis and Enzyme Engineering)
Mycotoxins are dangerous compounds and find multiple routes to enter living bodies of humans and animals. To solve the issue and degrade the toxicants, (bio)catalytic processes look very promising. Hexahistidine-tagged organophosphorus hydrolase (His6-OPH) is a well-studied catalyst for degradation of organophosphorus neurotoxins and lactone-containing quorum-sensing signal molecules. Moreover, the catalytic characteristics in hydrolysis of several mycotoxins (patulin, deoxynivalenol, zearalenone, and sterigmatocystin) were studied in this investigation. The best Michaelis constant and catalytic constant were estimated in the case of sterigmatocystin and patulin, respectively. A possible combination of His6-OPH with inorganic sorbents treated by low-temperature plasma was investigated. Further, enzyme–polyelectrolyte complexes of poly(glutamic acid) with His6-OPH and another enzymatic mycotoxin degrader (thermolysin) were successfully used to modify fiber materials. These catalytically active prototypes of protective materials appear to be useful for preventing surface contact and exposure to mycotoxins and other chemicals that are substrates for the enzymes used. View Full-Text
Keywords: mycotoxin; hydrolysis; organophosphorus hydrolase; sorbent; immobilization mycotoxin; hydrolysis; organophosphorus hydrolase; sorbent; immobilization
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MDPI and ACS Style

Lyagin, I.; Stepanov, N.; Maslova, O.; Senko, O.; Aslanli, A.; Efremenko, E. Not a Mistake but a Feature: Promiscuous Activity of Enzymes Meeting Mycotoxins. Catalysts 2022, 12, 1095. https://doi.org/10.3390/catal12101095

AMA Style

Lyagin I, Stepanov N, Maslova O, Senko O, Aslanli A, Efremenko E. Not a Mistake but a Feature: Promiscuous Activity of Enzymes Meeting Mycotoxins. Catalysts. 2022; 12(10):1095. https://doi.org/10.3390/catal12101095

Chicago/Turabian Style

Lyagin, Ilya, Nikolay Stepanov, Olga Maslova, Olga Senko, Aysel Aslanli, and Elena Efremenko. 2022. "Not a Mistake but a Feature: Promiscuous Activity of Enzymes Meeting Mycotoxins" Catalysts 12, no. 10: 1095. https://doi.org/10.3390/catal12101095

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