Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Evaluation
2.2. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. Pathological Features
3.3. Treatment and Outcome of Initial Tumor
3.4. Treatment and Outcome of Relapsed Tumor
3.5. Distant Metastases and Disease-Specific Survival
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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No. | Age (y) | Sex | Initial Presentation | Primary Site | Localization | Maximum Diameter (cm) | F/U Periods (m) |
---|---|---|---|---|---|---|---|
1 | 46 | F | Primary | Back | Deep | 2.5 | 113 |
2 | 58 | F | Primary | Neck | Deep | 3.5 | 101 |
3 | 48 | M | Primary | Abdominal wall | Superficial | 1 | 104 |
4 | 64 | M | Primary | Vocal cords | Deep | 1.4 | 34 |
5 | 30 | F | Primary | LE (ankle) | Superficial | 1.6 | 83 |
6 | 67 | M | Primary | Chest wall | Deep | 3 | 161 |
7 | 11 | M | Primary | UE (upper arm) | Superficial | 2.8 | 96 |
8 | 19 | F | Primary | LE (thigh) | Superficial | 3.7 | 94 |
9 | 12 | M | Primary | LE (foot) | Superficial | 2.8 | 118 |
10 | 36 | M | Primary | Back | Deep | 6.1 | 46 |
11 | 79 | F | Primary | UE (forearm) | Superficial | 4 | 50 |
12 | 27 | F | Relapse | UE (upper arm) | Superficial | 2.5 | 32 |
13 | 19 | F | Primary | Groin | Superficial | 3 | 55 |
14 | 68 | M | Primary | Buttock | Deep | 6.2 | 38 |
15 | 74 | F | Primary | LE (lower leg) | Deep | 9.5 | 54 |
16 | 33 | M | Primary | LE (thigh) | Deep | 2.8 | 73 |
17 | 26 | F | Primary | Axilla | Deep | 7 | 181 |
18 | 86 | F | Primary | LE (thigh) | Deep | 10 | 88 |
19 | 76 | F | Primary | Buttock | Superficial | 6.2 | 4 |
20 | 83 | F | Primary | Buttock | Superficial | 5.4 | 58 |
21 | 38 | F | Primary | Tongue | Superficial | 1.5 | 93 |
22 | 47 | M | Primary | Back | Deep | 4 | 11 |
23 | 28 | M | Primary | Neck | Deep | 14 | 121 |
24 | 22 | F | Primary | Neck | Deep | 7.2 | 75 |
No. | Treatment | Margin Status | Local Relapse | Metastases | Outcome |
---|---|---|---|---|---|
1 | Wide excision | R0 | - | - | CDF |
2 | Wide excision | R0 | - | - | CDF |
3 | Intralesional excision | R2 | - | - | AWD |
4 | Wide excision | R0 | - | - | CDF |
5 | Marginal excision | R1 | - | - | CDF |
6 | Wide excision | R0 | + | - | NED |
7 | Wide excision | R0 | - | - | CDF |
8 | Wide excision | R0 | - | - | CDF |
9 | Wide excision | R0 | - | - | CDF |
10 | Marginal excision + adjuvant RT (50 Gy) | R1 | - | - | CDF |
11 | Wide excision + adjuvant RT (48 Gy) | R1 | - | - | CDF |
12 | Wide excision | R1 | - | - | NED |
13 | Wide excision | R0 | - | - | CDF |
14 | Wide excision | R0 | - | - | CDF |
15 | Wide excision + adjuvant RT (60 Gy) | R0 | + | - | AWD |
16 | Wide excision | R0 | - | - | CDF |
17 | Marginal excision | R1 | + | - | NED |
18 | Wide excision + adjuvant RT (66 Gy) | R1 | - | - | CDF |
19 | Wide excision | R0 | - | - | CDF |
20 | Marginal excision | R1 | + | + | AWD |
21 | Wide excision | R0 | - | - | CDF |
22 | Wide excision | R0 | - | - | CDF |
23 | IMRT (60 Gy) | No surgery | - | - | CDF |
24 | IMRT (60 Gy) | No surgery | + | - | AWD |
Variables | n | 5-Year Survival (%) | p-Value |
---|---|---|---|
Age (years) | |||
45> | 12 | 83.3 | 0.52 |
45≤ | 12 | 63.4 | |
Sex | |||
male | 10 | 83.3 | 0.25 |
female | 14 | 68.4 | |
Primary site | |||
trunk | 10 | 57.1 | 0.68 |
head and neck | 5 | 80 | |
LE | 6 | 83.3 | |
UE | 3 | 100 | |
Localization | |||
deep | 13 | 63.5 | 0.19 |
superficial | 11 | 88.9 | |
Maximum diameter (cm) | |||
5> | 15 | 90.9 | <0.01 |
5≤ | 9 | 50.0 | |
Treatment | |||
surgery | 18 | 79 | 0.58 |
Surgery + adjuvant RT | 4 | 75 | |
RT | 2 | 50 | |
Surgical methods (only surgical cases) | |||
wide excision | 17 | 84.4 | 0.16 |
marginal + intra excision | 5 | 60.0 | |
Margin status (only surgical cases) | |||
R0 | 14 | 82.1 | 0.49 |
R1 + R2 | 8 | 72.9 | |
Ki-67 (%) | |||
10> | 12 | 71.4 | 0.78 |
10≤ | 12 | 79.5 |
No. (Refer to Table 1) | Time to Local Relapse (m) | Treatment | Margin Status | Best Overall Response | Re-Local Relapse | F/U Periods after Treatment (m) |
---|---|---|---|---|---|---|
6 | 53 | Surgery | R0 | N/A | - | 108 |
15 | 8 | RT (60 Gy) | No surgery | PR | - | 46 |
17 | 6 | Carbon ion RT (70.4 Gy) | No surgery | SD | - | 175 |
20 | 36 | Surgery | R0 | N/A | - | 22 |
24 | 31 | IMRT (60 Gy) | No surgery | PR | - | 43 |
Authors, Year of Publication | n | Local Relapse | Distant Metastases | ||||
---|---|---|---|---|---|---|---|
Simple Excision | Wide Excision | Excision + RT | Excision + Chemotherapy | Radical RT | |||
Mentzel et al., 1998 [1] | 11 | 28.6% (2/7) | 0% (0/1) | 0% (0/3) | N/A | N/A | 9.1% (1/11) |
Montgomery et al., 2001 [3] | 13 | 66.7% (6/9) | 50% (1/2) | 0% (0/2) | N/A | N/A | 7.7% (1/13) |
Meng et al., 2007 [4] | 14 | 12.5% (1/8) | 50% (1/2) | 75% (3/4) | N/A | 0% (0/14) | |
Kim et al., 2021 [5] | 15 | 100% (2/2) | 0% (0/13) | N/A | N/A | N/A | 0% (0/15) |
This study | 24 | 50% (2/4) | 7.1% (1/14) | 25% (1/4) | N/A | 50% (1/2) | 4.2% (1/24) |
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Kito, M.; Ae, K.; Okamoto, M.; Endo, M.; Ikuta, K.; Takeuchi, A.; Yasuda, N.; Yasuda, T.; Imura, Y.; Morii, T.; et al. Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group. Cancers 2023, 15, 2314. https://doi.org/10.3390/cancers15082314
Kito M, Ae K, Okamoto M, Endo M, Ikuta K, Takeuchi A, Yasuda N, Yasuda T, Imura Y, Morii T, et al. Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group. Cancers. 2023; 15(8):2314. https://doi.org/10.3390/cancers15082314
Chicago/Turabian StyleKito, Munehisa, Keisuke Ae, Masanori Okamoto, Makoto Endo, Kunihiro Ikuta, Akihiko Takeuchi, Naohiro Yasuda, Taketoshi Yasuda, Yoshinori Imura, Takeshi Morii, and et al. 2023. "Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group" Cancers 15, no. 8: 2314. https://doi.org/10.3390/cancers15082314