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Review

Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Sensing and Characterization of Exosomes in Cancer Diagnosis

1
Department of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Carrer de Marcel·li Domingo s/n, 43007 Tarragona, Spain
2
Fundación de Investigación HM Hospitales, San Bernardo 101, 28015 Madrid, Spain
3
School of Medicine, San Pablo CEU, Calle Julian Romea, 18, 28003 Madrid, Spain
4
Epigenetics & Cellular Senescence Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
5
Instituto de Estructura de la Materia (IEM-CSIC), Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain
6
Technology Innovation Institute, Masdar City, Abu Dhabi 9639, United Arab Emirates
7
ICREA, Passeig Lluis Companys 23, 08010 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Farrukh Aqil
Cancers 2021, 13(9), 2179; https://doi.org/10.3390/cancers13092179
Received: 24 March 2021 / Revised: 26 April 2021 / Accepted: 26 April 2021 / Published: 30 April 2021
(This article belongs to the Special Issue Exosomes in Cancers Therapy)
The distinct molecular and biological properties of exosomes, together with their abundance and stability, make them an ideal target in liquid biopsies for early diagnosis and disease monitoring. On the other hand, in recent years, nanomaterial-based optical biosensors have been extensively investigated as novel, rapid and sensitive tools for exosome detection and discrimination. The scope of this review is to summarize and coherently discussed the diverse applications, challenges and limitations of nanosensors based on surface-enhanced Raman spectroscopy (SERS) as the optosensing technique.
Exosomes are emerging as one of the most intriguing cancer biomarkers in modern oncology for early cancer diagnosis, prognosis and treatment monitoring. Concurrently, several nanoplasmonic methods have been applied and developed to tackle the challenging task of enabling the rapid, sensitive, affordable analysis of exosomes. In this review, we specifically focus our attention on the application of plasmonic devices exploiting surface-enhanced Raman spectroscopy (SERS) as the optosensing technique for the structural interrogation and characterization of the heterogeneous nature of exosomes. We summarized the current state-of-art of this field while illustrating the main strategic approaches and discuss their advantages and limitations. View Full-Text
Keywords: exosomes; cancer diagnosis; sensing; early detection; plasmonics; nanoparticles; surface-enhanced Raman spectroscopy exosomes; cancer diagnosis; sensing; early detection; plasmonics; nanoparticles; surface-enhanced Raman spectroscopy
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MDPI and ACS Style

Guerrini, L.; Garcia-Rico, E.; O’Loghlen, A.; Giannini, V.; Alvarez-Puebla, R.A. Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Sensing and Characterization of Exosomes in Cancer Diagnosis. Cancers 2021, 13, 2179. https://doi.org/10.3390/cancers13092179

AMA Style

Guerrini L, Garcia-Rico E, O’Loghlen A, Giannini V, Alvarez-Puebla RA. Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Sensing and Characterization of Exosomes in Cancer Diagnosis. Cancers. 2021; 13(9):2179. https://doi.org/10.3390/cancers13092179

Chicago/Turabian Style

Guerrini, Luca; Garcia-Rico, Eduardo; O’Loghlen, Ana; Giannini, Vincenzo; Alvarez-Puebla, Ramon A. 2021. "Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Sensing and Characterization of Exosomes in Cancer Diagnosis" Cancers 13, no. 9: 2179. https://doi.org/10.3390/cancers13092179

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