Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas
Programa de Carcinogênese Molecular, Instituto Nacional de Câncer—INCA, Rua André Cavalcanti, 37-Centro, Rio de Janeiro 20231-050, Brazil
Instituto de Ciências Biomédicas, Prédio de Ciências da Saúde—Cidade Universitária, Universidade Federal do Rio de Janeiro, Ilha do Fundão, A. Carlos Chagas, Rio de Janeiro 21941-902, Brazil
Laboratório de Interações Celulares, Instituto de Ciências Biomédicas, Prédio de Ciências da Saúde—Cidade Universitária, Universidade Federal do Rio de Janeiro—UFRJ, Ilha do Fundão, A. Carlos Chagas, 373-bloco F, sala 26, Rio de Janeiro 21941-902, Brazil
Author to whom correspondence should be addressed.
Academic Editor: David Wong
Received: 4 March 2021
Revised: 3 April 2021
Accepted: 8 April 2021
Published: 15 April 2021
Head and neck cancers (HNC) account for approximately 500,000 new cases of tumors annually worldwide and are represented by upper aerodigestive tract malignant neoplasms, which particularly arise in oral cavity, larynx, and pharynx tissues. Thus, due to the biological diversity between the upper aerodigestive organs, and to the heterogeneity of risk factors associated with their malignant transformation, HNC behavior, and prognosis seem to strongly vary according to the tumor site. However, despite to the heterogeneity which characterizes head and neck tumors, squamous cell carcinomas (SCC) represent the predominant histopathologic HNC subtype. In this sense, it has been reported that SCC tumor biology is strongly associated with deregulations within the extracellular matrix compartment. Accordingly, it has been shown that laminin plays a remarkable role in the regulation of crucial events associated with head and neck squamous cell carcinomas (HNSCC) progression, which opens the possibility that laminin may represent a convergence point in HNSCC natural history.