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Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas

1
Programa de Carcinogênese Molecular, Instituto Nacional de Câncer—INCA, Rua André Cavalcanti, 37-Centro, Rio de Janeiro 20231-050, Brazil
2
Instituto de Ciências Biomédicas, Prédio de Ciências da Saúde—Cidade Universitária, Universidade Federal do Rio de Janeiro, Ilha do Fundão, A. Carlos Chagas, Rio de Janeiro 21941-902, Brazil
3
Laboratório de Interações Celulares, Instituto de Ciências Biomédicas, Prédio de Ciências da Saúde—Cidade Universitária, Universidade Federal do Rio de Janeiro—UFRJ, Ilha do Fundão, A. Carlos Chagas, 373-bloco F, sala 26, Rio de Janeiro 21941-902, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: David Wong
Cancers 2021, 13(8), 1890; https://doi.org/10.3390/cancers13081890
Received: 4 March 2021 / Revised: 3 April 2021 / Accepted: 8 April 2021 / Published: 15 April 2021
Head and neck cancers (HNC) account for approximately 500,000 new cases of tumors annually worldwide and are represented by upper aerodigestive tract malignant neoplasms, which particularly arise in oral cavity, larynx, and pharynx tissues. Thus, due to the biological diversity between the upper aerodigestive organs, and to the heterogeneity of risk factors associated with their malignant transformation, HNC behavior, and prognosis seem to strongly vary according to the tumor site. However, despite to the heterogeneity which characterizes head and neck tumors, squamous cell carcinomas (SCC) represent the predominant histopathologic HNC subtype. In this sense, it has been reported that SCC tumor biology is strongly associated with deregulations within the extracellular matrix compartment. Accordingly, it has been shown that laminin plays a remarkable role in the regulation of crucial events associated with head and neck squamous cell carcinomas (HNSCC) progression, which opens the possibility that laminin may represent a convergence point in HNSCC natural history.
Head and neck squamous cell carcinomas (HNSCC) are among the most common and lethal tumors worldwide, occurring mostly in oral cavity, pharynx, and larynx tissues. The squamous epithelia homeostasis is supported by the extracellular matrix (ECM), and alterations in this compartment are crucial for cancer development and progression. Laminin is a fundamental component of ECM, where it represents one of the main components of basement membrane (BM), and data supporting its contribution to HNSCC genesis and progression has been vastly explored in oral cavity squamous cell carcinoma. Laminin subtypes 111 (LN-111) and 332 (LN-332) are the main isoforms associated with malignant transformation, contributing to proliferation, adhesion, migration, invasion, and metastasis, due to its involvement in the regulation of several pathways associated with HNSCC carcinogenesis, including the activation of the EGFR/MAPK signaling pathway. Therefore, it draws attention to the possibility that laminin may represent a convergence point in HNSCC natural history, and an attractive potential therapeutic target for these tumors. View Full-Text
Keywords: head and neck cancer; oral cancer; pharyngeal cancer; laryngeal cancer; extracellular matrix; laminin; Laminin-111; Laminin-332; Laminin γ2; LAMC2 head and neck cancer; oral cancer; pharyngeal cancer; laryngeal cancer; extracellular matrix; laminin; Laminin-111; Laminin-332; Laminin γ2; LAMC2
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MDPI and ACS Style

Meireles Da Costa, N.; Mendes, F.A.; Pontes, B.; Nasciutti, L.E.; Ribeiro Pinto, L.F.; Palumbo Júnior, A. Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas. Cancers 2021, 13, 1890. https://doi.org/10.3390/cancers13081890

AMA Style

Meireles Da Costa N, Mendes FA, Pontes B, Nasciutti LE, Ribeiro Pinto LF, Palumbo Júnior A. Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas. Cancers. 2021; 13(8):1890. https://doi.org/10.3390/cancers13081890

Chicago/Turabian Style

Meireles Da Costa, Nathalia, Fábio A. Mendes, Bruno Pontes, Luiz E. Nasciutti, Luis F. Ribeiro Pinto, and Antonio Palumbo Júnior. 2021. "Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas" Cancers 13, no. 8: 1890. https://doi.org/10.3390/cancers13081890

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