Pulsed Dose Rate Brachytherapy of Lip Carcinoma: Clinical Outcome and Quality of Life Analysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patients Characteristics
2.2. Brachytherapy Procedure
2.3. Follow-Up
3. Results
3.1. Patients Characteristics and Treatment Data
3.2. Toxicity
3.3. Quality of Life Analysis
3.4. Tumor Control Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | n/Median | Min–Max/% | |
---|---|---|---|
Age | 73 | 35–92 | |
Gender | |||
F | 9 | 23.7 | |
M | 29 | 76.3 | |
Performance status | |||
0 | 17 | 44.8 | |
1 | 20 | 52.6 | |
2 | 0 | 0 | |
3 | 1 | 2.6 | |
Tobacco | |||
0 | 17 | 44.7 | |
withdrawn | 16 | 42.1 | |
active | 5 | 13.2 | |
Histology | |||
squamous cell carcinoma | 37 | 97 | |
polymorph adenocarcinoma | 1 | 2.6 | |
Tumor localization | |||
lower lip | 28 | 73.7 | |
upper lip | 8 | 28 | |
lip and cheek | 2 | 5.3 | |
T | |||
1 | 14 | 36.9 | |
2 | 16 | 42.1 | |
3 | 7 | 18.4 | |
4 | 1 | 2.6 | |
n | |||
0 | 34 | 89.5 | |
1 | 2 | 5.3 | |
2 | 2 | 5.3 | |
M | |||
0 | 38 | 100 | |
1 | 0 | 0 |
Treatment Data | Median | Min–Max | n |
---|---|---|---|
Catheters number | 4 | 15–2 | 38 |
Plans number | 2 | 4–1 | 37 |
Catheters spacing | 13 | 18–9 | 37 |
Length activation | 65 | 50–120 | 38 |
Dose/pulse (cGy) | 42 | 40–50 | 38 |
Pulse number | 166.5 | 120–179 | 38 |
Total dose (Gy) | 70.14 | 60–85 | 38 |
V 100% (cm3) | 16.49 | 4.7–47.8 | 34 |
V 150% (cm3) | 4.45 | 2.3–14.1 | 33 |
V 200% (cm3) | 2.1 | 1–5.8 | 33 |
TRAK (mGy) | 1.82 | 0.77–3.36 | 37 |
mandible D2cc (Gy) | 28.6 | 7.2–49.4 | 31 |
mandible D0.1cc (Gy) | 42.6 | 9.1–82.8 | 31 |
mandible D0.01cc (Gy) | 48.4 | 11.8–101 | 31 |
Toxicity Data (Grade) | n | % | |
---|---|---|---|
Radiomucitis | |||
G0 | 0 | 0% | |
G1 | 2 | 6% | |
G2 | 19 | 53% | |
G3 | 15 | 42% | |
Odynophagia | |||
G0 | 20 | 56 | |
G1 | 13 | 36 | |
G2 | 3 | 8 | |
G3 | 0 | 0 | |
Fibrosis | |||
G0 | 15 | 42 | |
G1 | 18 | 50 | |
G2 | 3 | 8 | |
G3 | 0 | 0 | |
Chronic pain | |||
G0 | 32 | 89 | |
G1 | 3 | 8 | |
G2 | 1 | 3 | |
G3 | 0 | 0 | |
Depigmentation | |||
G0 | 19 | 53 | |
G1 | 17 | 47 | |
G2 | 0 | 0 |
Quality of Life Assessment | n/Median | %/Min–Max | |
---|---|---|---|
Would You Recommend the Treatment? | |||
0 (not at all) | 0 | 0% | |
1 | 0 | 0% | |
2 | 0 | 0% | |
3-neutral | 0 | 0% | |
4 | 2 | 18% | |
5 (definitively) | 9 | 82% | |
FACT H&N scores (range) | |||
Physical well-being score (0–28) | 25 | 15–27 | |
Social/family well-being score (0–28) | 26.8 | 1.2–28 | |
Emotional well-being score (0–24) | 19 | 14–24 | |
Functional well-being score (0–28) | 23 | 11–28 | |
Head and Neck cancer subscale (0–40) | 36 | 25–40 | |
FACT H&N Trial Outcome Index (0–96) | 84 | 58.2–94 | |
FACT H&N total score (0–148) | 127 | 75.4–146 |
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El Ayachy, R.; Sun, R.; Ka, K.; Laville, A.; Duhamel, A.-S.; Tailleur, A.; Dumas, I.; Bockel, S.; Espenel, S.; Blanchard, P.; et al. Pulsed Dose Rate Brachytherapy of Lip Carcinoma: Clinical Outcome and Quality of Life Analysis. Cancers 2021, 13, 1387. https://doi.org/10.3390/cancers13061387
El Ayachy R, Sun R, Ka K, Laville A, Duhamel A-S, Tailleur A, Dumas I, Bockel S, Espenel S, Blanchard P, et al. Pulsed Dose Rate Brachytherapy of Lip Carcinoma: Clinical Outcome and Quality of Life Analysis. Cancers. 2021; 13(6):1387. https://doi.org/10.3390/cancers13061387
Chicago/Turabian StyleEl Ayachy, Radouane, Roger Sun, Kanta Ka, Adrien Laville, Anne-Sophie Duhamel, Anne Tailleur, Isabelle Dumas, Sophie Bockel, Sophie Espenel, Pierre Blanchard, and et al. 2021. "Pulsed Dose Rate Brachytherapy of Lip Carcinoma: Clinical Outcome and Quality of Life Analysis" Cancers 13, no. 6: 1387. https://doi.org/10.3390/cancers13061387