In the original article, there was a mistake in Figure 3 as published [1]. The image presented corresponded to endometrial cancer-specific mortality cumulative incidence, instead of the figure referred to in the title (all-cause mortality cumulative incidence).
The corrected Figure 3 appears below:
Figure 3.
All-cause mortality cumulative incidence in females with Lynch syndrome comparing risk reducing gynecological surgery and non-risk reducing gynecological surgery: All-cause mortality cumulative incidence was 0.0% for risk reducing gynecological surgery vs. 52.7% for non-risk reducing gynecological surgery (p = not assessable).
The study carried out is an analysis of cumulative incidence of mortality and not an analysis of overall survival, as explicitly reported in the methodology section (Sections 4.3 and 4.4). Our study, like other retrospective studies could suffer from bias. For that reason, we did a balanced discussion of the strengths and weaknesses of our work in the Discussion section (paragraphs 11, 13 and 14) discussing limitations of retrospective studies, possible cohort effects, selection of patients based on clinical characteristics, etc.). Moreover, to facilitate the reader’s understanding of the text, we would like to refine the conclusions of our work as follows, making them more precise:
“In conclusion, this study confirms that colonic and gynecological risk reducing surgeries are effective at decreasing the incidence of metachronous colorectal and gynecological cancer in Lynch syndrome (LS) patients. This benefit was seen in all LS subjects; however, caution is still needed for MSH6 and PMS2 pathogenic variant carriers. Also, our results point to a reduction in the endometrial and ovarian cancer-specific mortality cumulative incidence in females with LS that undergo risk reducing gynecological surgery. Differences in all-cause mortality cumulative incidence should be confirmed in prospective analyses.”
The authors apologize for any inconvenience. All the authors have checked and agreed with the corrected paper content. The original article has been updated.
Conflicts of Interest
The authors declare no conflict of interest.
Reference
- Dueñas, N.; Navarro, M.; Teulé, À.; Solanes, A.; Salinas, M.; Iglesias, S.; Munté, E.; Ponce, J.; Guardiola, J.; Kreisler, E.; et al. Assessing Effectiveness of Colonic and Gynecological Risk Reducing Surgery in Lynch Syndrome Individuals. Cancers 2020, 12, 3419. [Google Scholar] [CrossRef] [PubMed]
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