Next Article in Journal
Current and Future Treatments in the Fight against Non-Alcoholic Fatty Liver Disease
Previous Article in Journal
Single-Drug Approach with Edoxaban is Effective for Resolving Non-Acute Cancer-Associated Venous Thrombosis: A Single-Arm Retrospective Analysis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 12
Issue 7
10.3390/cancers12071712
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Vitamin A Rich Diet Diminishes Early Urothelial Carcinogenesis by Altering Retinoic Acid Signaling

by
Daša Zupančič
1,†,
Jelena Korać-Prlić
2,†,
Mateja Erdani Kreft
1,
Lucija Franković
2,
Katarina Vilović
3,
Jera Jeruc
4,
Rok Romih
1,* and
Janoš Terzić
2,*
1
Institute of Cell Biology, Faculty of Medicine, University of Ljubljana,1000 Ljubljana, Slovenia
2
Laboratory for Cancer Research, School of Medicine, University of Split, 21000 Split, Croatia
3
Department of Pathology, University Hospital of Split, 21000 Split, Croatia
4
Institute of Pathology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cancers 2020, 12(7), 1712; https://doi.org/10.3390/cancers12071712
Submission received: 23 April 2020 / Revised: 17 June 2020 / Accepted: 18 June 2020 / Published: 28 June 2020
(This article belongs to the Section Molecular Cancer Biology)
Browse Figures
Review Reports Versions Notes

Abstract

Urinary bladder cancer is one of the leading malignancies worldwide, with the highest recurrence rates. A diet rich in vitamin A has proven to lower the risk of cancer, yet the molecular mechanisms underlying this effect are unknown. We found that vitamin A decreased urothelial atypia and apoptosis during early bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). Vitamin A did not alter urothelial cell desquamation, differentiation, or proliferation rate. Genes like Wnt5a, involved in retinoic acid signaling, and transcription factors Pparg, Ppara, Rxra, and Hoxa5 were downregulated, while Sox9 and Stra6 were upregulated in early urothelial carcinogenesis. When a vitamin A rich diet was provided during BBN treatment, none of these genes was up- or downregulated; only Lrat and Neurod1 were upregulated. The lecithin retinol acyltransferase (LRAT) enzyme that produces all-trans retinyl esters was translocated from the cytoplasm to the nuclei in urothelial cells as a consequence of BBN treatment regardless of vitamin A rich diet. A vitamin A-rich diet altered retinoic acid signaling, decreased atypia and apoptosis of urothelial cells, and consequently diminished early urothelial carcinogenesis.
Keywords: urinary bladder; early carcinogenesis; vitamin A; retinoic acid signaling; apoptosis urinary bladder; early carcinogenesis; vitamin A; retinoic acid signaling; apoptosis
Graphical Abstract

Share and Cite

MDPI and ACS Style

Zupančič, D.; Korać-Prlić, J.; Kreft, M.E.; Franković, L.; Vilović, K.; Jeruc, J.; Romih, R.; Terzić, J. Vitamin A Rich Diet Diminishes Early Urothelial Carcinogenesis by Altering Retinoic Acid Signaling. Cancers 2020, 12, 1712. https://doi.org/10.3390/cancers12071712

AMA Style

Zupančič D, Korać-Prlić J, Kreft ME, Franković L, Vilović K, Jeruc J, Romih R, Terzić J. Vitamin A Rich Diet Diminishes Early Urothelial Carcinogenesis by Altering Retinoic Acid Signaling. Cancers. 2020; 12(7):1712. https://doi.org/10.3390/cancers12071712

Chicago/Turabian Style

Zupančič, Daša, Jelena Korać-Prlić, Mateja Erdani Kreft, Lucija Franković, Katarina Vilović, Jera Jeruc, Rok Romih, and Janoš Terzić. 2020. "Vitamin A Rich Diet Diminishes Early Urothelial Carcinogenesis by Altering Retinoic Acid Signaling" Cancers 12, no. 7: 1712. https://doi.org/10.3390/cancers12071712

APA Style

Zupančič, D., Korać-Prlić, J., Kreft, M. E., Franković, L., Vilović, K., Jeruc, J., Romih, R., & Terzić, J. (2020). Vitamin A Rich Diet Diminishes Early Urothelial Carcinogenesis by Altering Retinoic Acid Signaling. Cancers, 12(7), 1712. https://doi.org/10.3390/cancers12071712

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop