A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer
Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi’an 710072, China
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Cancers 2020, 12(2), 352; https://doi.org/10.3390/cancers12020352
Received: 5 January 2020 / Revised: 29 January 2020 / Accepted: 31 January 2020 / Published: 4 February 2020
The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (ULK1) is a serine/threonine kinase that participates in the initiation of autophagy. Many studies have indicated that compounds that directly or indirectly target ULK1 could be used for tumor therapy. However, reports of the therapeutic effects of these compounds have come to conflicting conclusions. In this work, we reviewed recent studies related to the effects of ULK1 on the regulation of autophagy and the development of drug resistance in cancers, with the aim of clarifying the mechanistic underpinnings of this therapeutic target.
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Keywords:
ULK1; autophagy; cancer; drug resistance
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MDPI and ACS Style
Liu, L.; Yan, L.; Liao, N.; Wu, W.-Q.; Shi, J.-L. A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer. Cancers 2020, 12, 352. https://doi.org/10.3390/cancers12020352
AMA Style
Liu L, Yan L, Liao N, Wu W-Q, Shi J-L. A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer. Cancers. 2020; 12(2):352. https://doi.org/10.3390/cancers12020352
Chicago/Turabian StyleLiu, Li; Yan, Lu; Liao, Ning; Wu, Wan-Qin; Shi, Jun-Ling. 2020. "A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer" Cancers 12, no. 2: 352. https://doi.org/10.3390/cancers12020352
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