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MicroRNAs and Metastasis
Open AccessReview

Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis

Jagiellonian University Medical College, Faculty of Medicine, Institute of Pediatrics, Department of Transplantation, Wielicka 265, 30-663 Cracow, Poland
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Cancers 2020, 12(1), 209; https://doi.org/10.3390/cancers12010209
Received: 20 November 2019 / Revised: 20 December 2019 / Accepted: 9 January 2020 / Published: 14 January 2020
(This article belongs to the Special Issue Role of miRNAs in Cancer—Analysis of Their Targetome)
SNAIL (SNAI1) is a zinc finger transcription factor that binds to E-box sequences and regulates the expression of genes. It usually acts as a gene repressor, but it may also activate the expression of genes. SNAIL plays a key role in the regulation of epithelial to mesenchymal transition, which is the main mechanism responsible for the progression and metastasis of epithelial tumors. Nevertheless, it also regulates different processes that are responsible for tumor growth, such as the activity of cancer stem cells, the control of cell metabolism, and the regulation of differentiation. Different proteins and microRNAs may regulate the SNAIL level, and SNAIL may be an important regulator of microRNA expression as well. The interplay among SNAIL, microRNAs, long non-coding RNAs, and circular RNAs is a key event in the regulation of tumor growth and metastasis. This review for the first time discusses different types of regulation between SNAIL and non-coding RNAs with a focus on feedback loops and the role of competitive RNA. Understanding these mechanisms may help develop novel therapeutic strategies against cancer based on microRNAs. View Full-Text
Keywords: tumor; metastasis; microRNA; SNAIL (SNAI1) transcription factor; epithelial to mesenchymal transition (EMT); long non-coding RNAs (lncRNAs); circular RNAs tumor; metastasis; microRNA; SNAIL (SNAI1) transcription factor; epithelial to mesenchymal transition (EMT); long non-coding RNAs (lncRNAs); circular RNAs
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Skrzypek, K.; Majka, M. Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis. Cancers 2020, 12, 209.

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