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Cortactin: A Major Cellular Target of the Gastric Carcinogen Helicobacter pylori

Division of Microbiology, Department of Biology, Friedrich Alexander University Erlangen-Nuremberg, Staudtstr. 5, D-91058 Erlangen, Germany
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Cancers 2020, 12(1), 159; https://doi.org/10.3390/cancers12010159
Received: 5 December 2019 / Revised: 4 January 2020 / Accepted: 6 January 2020 / Published: 9 January 2020
Cortactin is an actin binding protein and actin nucleation promoting factor regulating cytoskeletal rearrangements in nearly all eukaryotic cell types. From this perspective, cortactin poses an attractive target for pathogens to manipulate a given host cell to their own benefit. One of the pathogens following this strategy is Helicobacter pylori, which can cause a variety of gastric diseases and has been shown to be the major risk factor for the onset of gastric cancer. During infection of gastric epithelial cells, H. pylori hijacks the cellular kinase signaling pathways, leading to the disruption of key cell functions. Specifically, by overruling the phosphorylation status of cortactin, H. pylori alternates the activity of molecular interaction partners of this important protein, thereby manipulating the performance of actin-cytoskeletal rearrangements and cell movement. In addition, H. pylori utilizes a unique mechanism to activate focal adhesion kinase, which subsequently prevents host epithelial cells from extensive lifting from the extracellular matrix in order to achieve chronic infection in the human stomach. View Full-Text
Keywords: Abl; Src; CagA; cagPAI; FAK; Helicobacter pylori; signaling; type IV secretion; T4SS; tyrosine kinases; SHP2 Abl; Src; CagA; cagPAI; FAK; Helicobacter pylori; signaling; type IV secretion; T4SS; tyrosine kinases; SHP2
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Sharafutdinov, I.; Backert, S.; Tegtmeyer, N. Cortactin: A Major Cellular Target of the Gastric Carcinogen Helicobacter pylori. Cancers 2020, 12, 159.

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