Next Article in Journal
Cardiovascular Organ Damage and Blood Pressure Levels Predict Adverse Events in Multiple Myeloma Patients Undergoing Carfilzomib Therapy
Previous Article in Journal
Rearranged During Transfection Fusions in Non-Small Cell Lung Cancer
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview

Homeobox Genes and Hepatocellular Carcinoma

Graduate Institute of Medicine, College of Medicine, Koahiusng 807, Taiwan
Department of Medical Research, Kaohsiung Medical University Hospital, Koahiusng 807, Taiwan
Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Koahiusng 807, Taiwan
Department of Surgery, Faculty of Medicine, Kaohsiung Medical University, Koahiusng 807, Taiwan
Authors to whom correspondence should be addressed.
Cancers 2019, 11(5), 621;
Received: 15 March 2019 / Revised: 27 April 2019 / Accepted: 27 April 2019 / Published: 3 May 2019
PDF [647 KB, uploaded 3 May 2019]


Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, and is the third leading cause of cancer-related deaths each year. It involves a multi-step progression and is strongly associated with chronic inflammation induced by the intake of environmental toxins and/or viral infections (i.e., hepatitis B and C viruses). Although several genetic dysregulations are considered to be involved in disease progression, the detailed regulatory mechanisms are not well defined. Homeobox genes that encode transcription factors with homeodomains control cell growth, differentiation, and morphogenesis in embryonic development. Recently, more aberrant expressions of Homeobox genes were found in a wide variety of human cancer, including HCC. In this review, we summarize the currently available evidence related to the role of Homeobox genes in the development of HCC. The objective is to determine the roles of this conserved transcription factor family and its potential use as a therapeutic target in future investigations. View Full-Text
Keywords: Homeobox; HCC; EMT; immunosuppression; IL6 Homeobox; HCC; EMT; immunosuppression; IL6

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Liu, K.-Y.; Wang, L.-T.; Hsu, S.-H.; Wang, S.-N. Homeobox Genes and Hepatocellular Carcinoma. Cancers 2019, 11, 621.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top