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Cancers 2019, 11(3), 322; https://doi.org/10.3390/cancers11030322

The Transient Receptor Potential Vanilloid Type-2 (TRPV2) Ion Channels in Neurogenesis and Gliomagenesis: Cross-Talk between Transcription Factors and Signaling Molecules

1
School of Pharmacy, University of Camerino, 62032 Camerino, Italy
2
School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy
*
Author to whom correspondence should be addressed.
Received: 2 February 2019 / Revised: 27 February 2019 / Accepted: 1 March 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Ion Channels in Cancer)
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Abstract

Recently, the finding of cancer stem cells in brain tumors has increased the possibilities
for advancing new therapeutic approaches with the aim to overcome the limits of current available
treatments. In addition, a role for ion channels, particularly of TRP channels, in developing neurons
as well as in brain cancer development and progression have been demonstrated. Herein, we focus
on the latest advancements in understanding the role of TRPV2, a Ca2+ permeable channel belonging
to the TRPV subfamily in neurogenesis and gliomagenesis. TRPV2 has been found to be expressed
in both neural progenitor cells and glioblastoma stem/progenitor-like cells (GSCs). In developing
neurons, post-translational modifications of TRPV2 (e.g., phosphorylation by ERK2) are required to
stimulate Ca2+ signaling and nerve growth factor-mediated neurite outgrowth. TRPV2
overexpression also promotes GSC differentiation and reduces gliomagenesis in vitro and in vivo.
In glioblastoma, TRPV2 inhibits survival and proliferation, and induces Fas/CD95-dependent
apoptosis. Furthermore, by proteomic analysis, the identification of a TRPV2 interactome-based
signature and its relation to glioblastoma progression/recurrence, high or low overall survival and
drug resistance strongly suggest an important role of the TRPV2 channel as a potential biomarker
in glioblastoma prognosis and therapy. View Full-Text
Keywords: TRPV2; gliomagenesis; glioblastoma stem cells; neurogenesis; cancer stem cells; ion channels TRPV2; gliomagenesis; glioblastoma stem cells; neurogenesis; cancer stem cells; ion channels
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Santoni, G.; Amantini, C. The Transient Receptor Potential Vanilloid Type-2 (TRPV2) Ion Channels in Neurogenesis and Gliomagenesis: Cross-Talk between Transcription Factors and Signaling Molecules. Cancers 2019, 11, 322.

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